Social status predicts physiological and behavioral responses to chronic stress in rhesus monkeys

Abstract

Investigating the underlying factors that cause differential individual responses to chronic stress is crucial for developing personalized therapies, especially in the face of pandemics such as COVID-19. However, this question remains elusive, particularly in primates. In the present study, we aimed to address this question by utilizing monkeys as a model to examine the impacts of social rank on stress levels and physiological and behavioral responses to chronic stress primarily caused by social isolation at both the individual and group levels. Our results showed that high-ranking animals were more susceptible to chronic stress. After exposure to chronic stress, although social hierarchies remained the same, the colonies exhibited more harmonious group relationships (e.g., more prosocial behaviors), with notable contributions from low-ranking animals. Overall, this study deepens our understanding of how social status shapes responses to chronic stress and sheds light on developing tailored and personalized therapies for coping with chronic stress.