Advances in Nanotechnology for Enhancing the Solubility and Bioavailability of Poorly Soluble Drugs

Yifan Liu(Shandong University of Traditional Chinese Medicine), Yushan Liang(Shandong University of Traditional Chinese Medicine), Jing Yuhong(Shandong University of Traditional Chinese Medicine), Peng Xin(Shandong University of Traditional Chinese Medicine), Jia Han(Shandong University of Traditional Chinese Medicine), Yongle Du(Shandong University of Traditional Chinese Medicine), Xinru Yu(Shandong University of Traditional Chinese Medicine), Runhe Zhu(Shandong University of Traditional Chinese Medicine), Mingxun Zhang(Shandong University of Traditional Chinese Medicine), Wen Chen(Shandong University of Traditional Chinese Medicine), Yingjie Ma(Shandong University of Traditional Chinese Medicine)
Drug Design Development and Therapy
May 1, 2024
10.2147/dddt.s447496
Cited by 278Open Access
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Abstract

This manuscript offers a comprehensive overview of nanotechnology's impact on the solubility and bioavailability of poorly soluble drugs, with a focus on BCS Class II and IV drugs. We explore various nanoscale drug delivery systems (NDDSs), including lipid-based, polymer-based, nanoemulsions, nanogels, and inorganic carriers. These systems offer improved drug efficacy, targeting, and reduced side effects. Emphasizing the crucial role of nanoparticle size and surface modifications, the review discusses the advancements in NDDSs for enhanced therapeutic outcomes. Challenges such as production cost and safety are acknowledged, yet the potential of NDDSs in transforming drug delivery methods is highlighted. This contribution underscores the importance of nanotechnology in pharmaceutical engineering, suggesting it as a significant advancement for medical applications and patient care.

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