Gut microbiota regulates host melatonin production through epithelial cell MyD88
Bingnan Liu(South China Agricultural University), Lijuan Fan(South China Agricultural University), Youxia Wang(South China Agricultural University), Hao Wang(South China Agricultural University), Yuqi Yan(Zhejiang University), Shuai Chen(University of Chinese Academy of Sciences), Ifen Hung, Chunxue Liu, Hong Wei(Huazhong Agricultural University), Liangpeng Ge(Chongqing Academy of Animal Science), Wenkai Ren(South China Agricultural University)
Cited by 36Open Access
Abstract
activated the TLR2/4/MyD88/NF-κB signaling pathway to promote expression of arylalkylamine N-acetyltransferase (AANAT, a rate-limiting enzyme for melatonin production), and MyD88 deficiency in colonic epithelial cells abolished the influence of intestinal microbiota on colonic melatonin production. Collectively, we revealed a specific underlying mechanism of gut microbiota to modulate host melatonin production, which might provide novel therapeutic ideas for melatonin-related diseases.
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