The Mutographs biorepository: A unique genomic resource to study cancer around the world

Sandra Pérdomo(Centre international de recherche sur le cancer), Behnoush Abedi‐Ardekani(Centre international de recherche sur le cancer), Ana Carolina de Carvalho(Centre international de recherche sur le cancer), Aida Ferreiro-Iglesias(Centre international de recherche sur le cancer), Valérie Gaborieau(Centre international de recherche sur le cancer), Thomas Cattiaux(Centre international de recherche sur le cancer), Hélène Renard(Centre international de recherche sur le cancer), Priscilia Chopard(Centre international de recherche sur le cancer), Christine Carreira(Centre international de recherche sur le cancer), Andreea Spanu(Centre international de recherche sur le cancer), Arash Nikmanesh(Centre international de recherche sur le cancer), Ricardo Cortez Cardoso Penha(Centre international de recherche sur le cancer), Samuel O. Antwi(Jacksonville College), Patrícia Ashton‐Prolla(Universidade Federal do Rio Grande do Sul), Cristina Canova(University of Padua), Taned Chitapanarux(Chiang Mai University), Riley Cox(Ontario Institute for Cancer Research), María Paula Curado(AC Camargo Hospital), José Carlos de Oliveira(Hospital Araújo Jorge), Charles P. Dzamalala(University of Malawi), Elenora Fabianova(Public Health Authority of the Slovak Republic), Lorenzo Ferri(McGill University), Rebecca C. Fitzgerald(University of Cambridge), Lenka Foretová(Masaryk Memorial Cancer Institute), Steven Gallinger(Mount Sinai Hospital), Alisa M. Goldstein(National Institutes of Health), Ivana Holcátová(Charles University), Antonio Huertas(Instituto Nacional de Cancerología), Vladimí­r Janout(Palacký University Olomouc), Sonata Jarmalaite(National Cancer Institute), Radka Kaneva(Medical University of Sofia), Luiz Paulo Kowalski(AC Camargo Hospital), Tomislav Kuliš(University Hospital Centre Zagreb), Παγώνα Λάγιου(National and Kapodistrian University of Athens), Jolanta Lissowska(National Institute of Oncology), Reza Malekzadeh(Tehran University of Medical Sciences), Dana Mateș, Valerie McCorrmack(Centre international de recherche sur le cancer), Diana Menya(Moi University), Sharayu Mhatre(Tata Memorial Hospital), Blandina T. Mmbaga(Santa Casa Hospital), André de Moricz(Kilimanjaro Christian Medical Centre), Péter Nyírády(Semmelweis University), Miodrag Ognjanovic(International Organization for Migration), Kyriaki Papadopoulou(Hellenic Cooperative Oncology Group), Jerry Polesel(Centro di Riferimento Oncologico), Mark P. Purdue(National Cancer Institute), Ștefan Rașcu(Carol Davila University of Medicine and Pharmacy), Lidia Maria Rebolho Batista(Hospital de Câncer de Barretos), Rui Manuel Reis(Hospital de Câncer de Barretos), Luís Felipe Ribeiro Pinto(Instituto Nacional de Câncer - INCA), Paula A. Rodríguez‐Urrego(AC Camargo Hospital), Surasak Sangkhathat(Prince of Songkla University), Suleeporn Sangrajrang(National Cancer Institute of Thailand), Tatsuhiro Shibata(National Cancer Research Institute), E. O. Stakhovsky(National Cancer Institute), Beata Świątkowska(Nofer Institute of Occupational Medicine), Carlos Vaccaro(Hospital Araújo Jorge), José Roberto Vasconcelos de Podestá(Feminist Center for Studies and Advisory Services), Naveen Vasudev(University of Leeds), Marta Vilensky(Universidad de Buenos Aires), Jonathan Yeung(University Health Network), Давид Заридзе(Russian Cancer Research Center NN Blokhin), Kazem Zendehdel(Tehran University of Medical Sciences), Ghislaine Scélo(Observational & Pragmatic Research Institute), Estelle Chanudet(Radboud University Nijmegen), Jingwei Wang(Wellcome Sanger Institute), Stephen Fitzgerald(Wellcome Sanger Institute), Calli Latimer(Wellcome Sanger Institute), Sarah Moody(Wellcome Sanger Institute), Laura Humphreys(Wellcome Sanger Institute), Ludmil B. Alexandrov(University of California San Diego), Michael R. Stratton(Wellcome Sanger Institute), Paul Brennan(AC Camargo Hospital)
Cell Genomics
February 6, 2024
10.1016/j.xgen.2024.100500
Cited by 16Open Access
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Abstract

Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 countries across five continents with extensive demographic, lifestyle, environmental, and clinical information. Whole-genome sequencing is being finalized for over 4,000 cases, with the primary goal of understanding the causes of cancer at eight anatomic sites. Genomic, exposure, and clinical data will be publicly available through the International Cancer Genome Consortium Accelerating Research in Genomic Oncology platform. The Mutographs sample and metadata biorepository constitutes a legacy resource for new projects and collaborations aiming to increase our current research efforts in cancer genomic epidemiology globally.

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