Mpox and Chickenpox Coinfection: Case Series From Southern Nigeria

Juliet Ijeoma Mmerem(University of Nigeria Teaching Hospital), Chukwudi Umenzekwe(Nnamdi Azikiwe University Teaching Hospital), Simon M Johnson(Federal University of Technology Owerri), Asukwo Onukak(University of Uyo Teaching Hospital), Nneka Marian Chika-Igwenyi(Federal Teaching Hospital Abakaliki), Sunday Kyrian Chukwu(Federal Teaching Hospital Abakaliki), Chizaram Onyeaghala(University of Port Harcourt Teaching Hospital), Jideofor Jacob Ozougwu(Federal University of Technology Owerri), Datonye Alasia(University of Port Harcourt Teaching Hospital), Odianosen Ehiakhamen(Nigeria Centre for Disease Control), Henry M. Nwankwo(Nnamdi Azikiwe University Teaching Hospital), Ogochukwu Ifeanyi Ezejiofor(Nnamdi Azikiwe University Teaching Hospital), Uche Unigwe(Federal Teaching Hospital Abakaliki), Michael Iroezindu(University of Nigeria Teaching Hospital)
The Journal of Infectious Diseases
December 7, 2023
10.1093/infdis/jiad556
Cited by 14

Abstract

BACKGROUND: We describe clinicoepidemiologic characteristics of mpox-chickenpox coinfection in Nigeria. METHODS: A retrospective cohort analysis was performed of confirmed mpox cases in Nigeria from January 2022 to March 2023. Mpox and chickenpox were confirmed by real-time polymerase chain reaction (RT-PCR). RESULTS: Of 94 (60.0%) suspected cases, 56 had confirmed mpox, of whom 16 (28.6%) had chickenpox coinfection. The median age of confirmed mpox cases was 29 years (interquartile range, 20-37 years), 24 were men (60.7%), 6 (10.7%) were bisexual, and 5 (8.9%) died. Mpox-chickenpox-coinfected patients had more complications than mpox-monoinfected cases (56.3% vs 22.5%, P = .015). CONCLUSIONS: The high frequency of mpox-chickenpox coinfection argues for accelerated access to mpox and chickenpox vaccines in Africa.

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