A genomic mutational constraint map using variation in 76,156 human genomes
Siwei Chen(Broad Institute), Laurent C. Francioli(Broad Institute), Julia K. Goodrich(Broad Institute), Ryan L. Collins(Broad Institute), Masahiro Kanai(Broad Institute), Qingbo S. Wang(Broad Institute), Jessica Alföldi(Broad Institute), Nicholas A. Watts(Broad Institute), Christopher Vittal(Broad Institute), Laura D. Gauthier(Broad Institute), Timothy Poterba(Broad Institute), Michael W. Wilson(Broad Institute), Yekaterina Tarasova(Broad Institute), William Phu(Broad Institute), Riley Grant(Broad Institute), Mary T. Yohannes(Broad Institute), Zan Koenig(Broad Institute), Yossi Farjoun, Eric Banks(Broad Institute), Stacey Donnelly(Broad Institute), Stacey Gabriel(Broad Institute), Namrata Gupta(Broad Institute), Steven Ferriera(Broad Institute), Charlotte Tolonen(Broad Institute), Sam Novod(Broad Institute), Louis Bergelson(Broad Institute), David Roazen(Broad Institute), Valentín Ruano-Rubio(Broad Institute), Miguel Covarrubias(Broad Institute), Christopher Llanwarne(Broad Institute), Nikelle Petrillo(Broad Institute), Gordon Wade(Broad Institute), Thibault Jeandet(Broad Institute), Ruchi Munshi(Broad Institute), Kathleen Tibbetts(Broad Institute), María T. Abreu(University of Miami), Carlos A. Aguilar‐Salinas(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán), Tariq Ahmad(Peninsula College of Medicine and Dentistry), Christine M. Albert(Brigham and Women's Hospital), Diego Ardissino(University of Parma), Irina M. Armean(Broad Institute), Elizabeth G. Atkinson(Broad Institute), Gil Atzmon(Albert Einstein College of Medicine), John Barnard(Cleveland Clinic Lerner College of Medicine), Samantha Baxter(Broad Institute), Laurent Beaugerie(Sorbonne Université), Emelia J. Benjamin(Boston University), David Benjamin(Broad Institute), Michael Boehnke(University of Michigan), Lori L. Bonnycastle(National Institutes of Health), Erwin P. Böttinger(Icahn School of Medicine at Mount Sinai), Donald W. Bowden(Wake Forest University), Matthew J. Bown(University of Leicester), Harrison Brand(Harvard University), Steven R. Brant(Rutgers, The State University of New Jersey), Ted Brookings(Broad Institute), Sam Bryant(Broad Institute), Sarah E. Calvo(Broad Institute), Hannia Campos(Harvard University), John C. Chambers(Imperial College Healthcare NHS Trust), Juliana C.N. Chan(Chinese University of Hong Kong), Katherine R. Chao(Broad Institute), Sinéad B. Chapman(Broad Institute), Daniel I. Chasman(Brigham and Women's Hospital), Rex L. Chisholm(Northwestern University), Judy H. Cho(Icahn School of Medicine at Mount Sinai), Rajiv Chowdhury(University of Cambridge), Mina K. Chung(Cleveland Clinic), Wendy K. Chung(Columbia University Irving Medical Center), Kristian Cibulskis(Broad Institute), Bruce M. Cohen(Harvard University), Kristen M. Connolly(Broad Institute), Adolfo Correa(Jackson Memorial Hospital), Beryl B. Cummings(Broad Institute), Dana Dabelea(Colorado School of Public Health), John Danesh(University of Cambridge), Dawood Darbar(University of Illinois Chicago), Phil Darnowsky(Broad Institute), Joshua C. Denny(Vanderbilt University Medical Center), Ravindranath Duggirala(Texas A&M University – San Antonio), Josée Dupuis(Boston University), Patrick T. Ellinor(Broad Institute), Roberto Elosúa(Universitat de Vic - Universitat Central de Catalunya), James Emery(Broad Institute), Eleina England(Broad Institute), Jeanette Erdmann(Technical University of Applied Sciences Lübeck), Tõnu Esko(Broad Institute), Emily Evangelista(Broad Institute), Diane Fatkin(Victor Chang Cardiac Research Institute), José C. Florez(Broad Institute), André Franke(Christian-Albrechts-Universität zu Kiel), Jack Fu(Broad Institute), Martti Färkkilâ(Helsinki University Hospital), Kiran Garimella(Broad Institute), Jeff Gentry(Broad Institute), Gad Getz(Broad Institute), David C. Glahn(Boston Children's Hospital), Benjamin Gläser(Hebrew University of Jerusalem), Stephen J. Glatt(SUNY Upstate Medical University), David B. Goldstein(Columbia University Irving Medical Center), Clicerio González(Instituto Nacional de Salud Pública), Leif Groop(University of Helsinki), Sanna Gudmundsson(Broad Institute), Andrea Haessly(Broad Institute), Christopher A. Haiman(University of Southern California), Ira M. Hall(Washington University in St. Louis), Craig L. Hanis(The University of Texas Health Science Center at Houston), Matthew Harms(Columbia University), Mikko Hiltunen(University of Eastern Finland), Matti Holi(Helsinki University Hospital), Christina M. Hultman(Karolinska Institutet), Chaim Jalas(Kingsbrook Jewish Medical Center), Mikko Kallela(Helsinki University Hospital), Diane Kaplan(Broad Institute), Jaakko Kaprio(University of Helsinki), Sekar Kathiresan(Broad Institute), Eimear E. Kenny(Genomic Health (United States)), Bong‐Jo Kim(Korea National Institute of Health), Young Jin Kim(Korea National Institute of Health), Daniel A. King(Broad Institute), George Kirov(Cardiff University), Jaspal S. Kooner(Imperial College Healthcare NHS Trust), Seppo Koskinen(Finnish Institute for Health and Welfare), Harlan M. Krumholz(Yale New Haven Hospital), Subra Kugathasan(Emory University), Soo Heon Kwak(Seoul National University Hospital), Markku Laakso(University of Eastern Finland), Nicole J. Lake(Yale University), Trevyn Langsford(Broad Institute), Kristen M. Laricchia(Broad Institute), Terho Lehtimäki(Tampere University of Applied Sciences), Monkol Lek(Yale University), Emily Lipscomb(Broad Institute), Ruth J. F. Loos(University of Copenhagen), Wenhan Lu(Broad Institute), Steven A. Lubitz(Broad Institute), Teresa Tusie Luna(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán), Ronald C.W.(Chinese University of Hong Kong), Gregory M. Marcus(University of California, San Francisco), Jaume Marrugat(Centro de Investigación en Red en Enfermedades Cardiovasculares), Kari M. Mattila(Tampere University of Applied Sciences), Steven A. McCarroll(Broad Institute), Mark I. McCarthy(Centre for Human Genetics), Jacob L. McCauley(University of Miami), Dermot McGovern(Cedars-Sinai Medical Center), Ruth McPherson(University of Ottawa), James B. Meigs(Broad Institute), Olle Melander(Malmö University), Andres Metspalu(University of Tartu), Deborah A. Meyers(University of Arizona), Eric Vallabh Minikel(Broad Institute), Braxton D. Mitchell(University of Maryland, Baltimore), Vamsi K. Mootha(Broad Institute), Aliya Naheed(International Centre for Diarrhoeal Disease Research), Saman Nazarian(Johns Hopkins University), Peter M. Nilsson(Lund University), Michael O‘Donovan(Cardiff University), Yukinori Okada(The University of Osaka), Döst Öngür(Harvard University), Lorena Orozco(National Institute of Genomic Medicine), Michael J. Owen(Cardiff University), Colin Palmer(University of Dundee), Nicholette D. Palmer(Wake Forest University), Aarno Palotie(Broad Institute), Kyong Soo Park(Seoul National University), Carlos N. Pato(University of Southern California), Ann E. Pulver(Johns Hopkins University), Dan Rader(Children's Hospital of Philadelphia), Nazneen Rahman(Institute of Cancer Research), Alex P. Reiner(University of Washington), Anne M. Remes(Oulu University Hospital), Dan Rhodes(Broad Institute), Stephen S. Rich(University of Virginia), John D. Rioux(Montreal Heart Institute), Samuli Ripatti(Broad Institute), Dan M. Roden(Vanderbilt University Medical Center), Jerome I. Rotter(UCLA Medical Center), Nareh Sahakian(Broad Institute), Danish Saleheen(Center for Non-Communicable Diseases), Veikko Salomaa(Finnish Institute for Health and Welfare), Andrea Saltzman(Broad Institute), Nilesh J. Samani(University of Leicester), Kaitlin E. Samocha(Broad Institute), Alba Sanchis-Juan(Massachusetts General Hospital), Jeremiah M. Scharf(Broad Institute), Molly Schleicher(Broad Institute), Heribert Schunkert(Deutsches Herzzentrum München), Sebastian Schönherr(Innsbruck Medical University), Eleanor G. Seaby(Broad Institute), Svati H. Shah(Duke University), Megan Shand(Broad Institute), Ted Sharpe(Broad Institute), M. Benjamin Shoemaker(Vanderbilt University), Tai E. Shyong(National University Hospital), Edwin K. Silverman(Brigham and Women's Hospital), Moriel Singer‐Berk(Broad Institute), Pamela Sklar(Icahn School of Medicine at Mount Sinai), Jonathan T. Smith(Broad Institute), J. G. Smith(Broad Institute), Hilkka Soininen(University of Eastern Finland), Harry Sokol(Inserm), Rachel G. Son(Broad Institute), José Soto(Broad Institute), Tim D. Spector(King's College London), Christine Stevens(Broad Institute), Nathan O. Stitziel(James S. McDonnell Foundation), Patrick F. Sullivan(University of North Carolina at Chapel Hill), Jaana Suvisaari(Finnish Institute for Health and Welfare), E Shyong Tai(National University of Singapore), Kent D. Taylor(UCLA Medical Center), Yik Ying Teo(National University of Singapore), Ming T. Tsuang(University of California San Diego), Tiinamaija Tuomi(University of Helsinki), Dan Turner(Hebrew University of Jerusalem), Teresa Tusié‐Luna(Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán), Erkki Vartiainen(University of Helsinki), Marquis P. Vawter(University of California, Irvine), Lily Wang(Broad Institute), Arcturus Wang(Broad Institute), James S. Ware(Broad Institute), Hugh Watkins(University of Oxford), Rinse K. Weersma(University Medical Center Groningen), Ben Weisburd(Broad Institute), Maija Wessman(University of Helsinki), Nicola Whiffin(Broad Institute), James G. Wilson(Beth Israel Deaconess Medical Center), Ramnik J. Xavier(Broad Institute), Anne O’Donnell‐Luria(Broad Institute), Matthew Solomonson(Broad Institute), Cotton Seed(Broad Institute), Alicia R. Martin(Broad Institute), Michael E. Talkowski(Broad Institute), Heidi L. Rehm(Broad Institute), Mark J. Daly(Broad Institute), Grace Tiao(Broad Institute), Benjamin M. Neale(Broad Institute), Daniel G. MacArthur(Broad Institute), Konrad J. Karczewski(Broad Institute)
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