Targeting mucosal-associated invariant T (MAIT) cells for immunotherapy of HCC
Benjamin Ruf(National Institutes of Health), Matthias Bruhns(University of Tübingen), S. Babaei(University of Tübingen), Noémi Kedei(National Institutes of Health), Lichun Ma(National Institutes of Health), Mahler Revsine(National Institutes of Health), Mohamed-Reda Benmebarek(National Institutes of Health), Chi Ma(National Institutes of Health), Bernd Heinrich(National Institutes of Health), V. Subramanyam(National Institutes of Health), Jin Qi(National Institutes of Health), Simon Wabitsch(National Institutes of Health), B. L. Green(National Institutes of Health), Kylynda C. Bauer(National Institutes of Health), Yuta Myojin(National Institutes of Health), Layla T. Greten(National Institutes of Health), Justin McCallen(National Institutes of Health), Patrick Huang(National Institutes of Health), Rajiv Trehan(National Institutes of Health), Xiaolin Wang(National Institutes of Health), Amran Nur(National Institutes of Health), Dana Q. M. Soika(National Institutes of Health), Marie Pouzolles(National Institutes of Health), Christine N. Evans(National Institutes of Health), Raj Chari(National Institutes of Health), David E. Kleiner(National Institutes of Health), William G. Telford(National Institutes of Health), Kimia Dadkhah(National Institutes of Health), Allison Ruchinskas(National Institutes of Health), Merrill K. Stovroff(Georgetown University), James D. Kang(Georgetown University), Kesha Oza(Georgetown University), Mathuros Ruchirawat(Chulabhorn Research Institute), Alexander Kroemer(Georgetown University), Xin Wei Wang(National Institutes of Health), Manfred Claassen(University of Tübingen), Firouzeh Korangy(National Institutes of Health), Tim F. Greten(National Institutes of Health)
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Abstract
Introduction The cellular composition of the hepatocellular carcinoma (HCC) tumor microenvironment (TME) has major impact on tumor initiation, progress, and therapy response. Mucosal-associated invariant T (MAIT) are an abundant T cell subtype in the human liver and play a crucial role in regulating immunity and inflammation. Yet, their role in HCC and their potential for cancer immunotherapy remains elusive.
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