Federal Clinical Guidelines on Vaccination of pneumococcal infection in children and adults

Abstract

Diseases of pneumococcal etiology are an actual problem of practical health care. S. pneumoniae continues to be one of the leading causes of serious illnesses in adults and children, such as bacteremia, otitis media, sinusitis, meningitis, and pneumonia. Vaccination is recognized as the most effective method of preventing pneumococcal infection, which is the only way to significantly affect morbidity, mortality and stop the growth of antibiotic resistance. The guidelines were developed based on an analysis of studies published over the past 5 years and included in the EMBASE, MEDLINE, PubMed databases and the Cochrane library. The results of the analysis were peer-reviewed by independent experts, taking into account the opinions of primary care practitioners. The quality and level of evidence generated, as well as the strength of the recommendations based on them, were assessed in accordance with international criteria. These clinical guidelines review the epidemiology, social significance, pathogenesis, clinical forms of pneumococcal infection, and characterize vaccines for its prevention. Recommendations for the vaccination of pneumococcal infection in children and adults, including those belonging to various risk groups and with various comorbid conditions, are presented. The target audience of these recommendations are medical specialists: pediatricians, epidemiologists, general practitioners (family doctors), therapists, allergists-immunologists, pulmonologists and others. They can also be useful for students of residency and postgraduate programs, students of advanced training courses in these specialties.