Development of an in vitro genotoxicity assay to detect retroviral vector-induced lymphoid insertional mutants
Antonella Lucía Bastone(Medizinische Hochschule Hannover), Violetta Dziadek(Medizinische Hochschule Hannover), Philipp John-Neek(Medizinische Hochschule Hannover), Friederike Mansel(Medizinische Hochschule Hannover), Jenni Fleischauer(Medizinische Hochschule Hannover), Eric Agyeman-Duah(Medizinische Hochschule Hannover), Dirk Schaudien(Fraunhofer Institute for Toxicology and Experimental Medicine), Oliver Dittrich‐Breiholz(Medizinische Hochschule Hannover), Adrian Schwarzer(Medizinische Hochschule Hannover), Axel Schambach(Boston Children's Hospital), Michael Rothe(Medizinische Hochschule Hannover)
Cited by 9Open Access
Abstract
, frequently observed in clinical trials with severe adverse events. Lymphoid insertional mutants displayed a unique gene expression signature identified by SAGA. The gene expression-based highly sensitive molecular readout will broaden our understanding of vector-induced oncogenicity and help in pre-clinical prediction of retroviral genotoxicity.
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