Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry
Antonia Sambola(Centro de Investigación en Red en Enfermedades Cardiovasculares), Jordi Lozano-Torres(Centro de Investigación en Red en Enfermedades Cardiovasculares), Eric Boersma(Erasmus MC), Carmen Olmos(Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Julien Ternacle(Hôpitaux Universitaires Henri-Mondor), Francisco Calvo(University Hospital Complex Of Vigo), Christophe Tribouilloy(Centre Hospitalier Universitaire Amiens-Picardie), Vlatka Rešković Lukšić(University Hospital Centre Zagreb), Jadranka Šeparović Hanževački(University Hospital Centre Zagreb), Seung Woo Park(Samsung Medical Center), Sebastiaan C.A.M. Bekkers(Maastricht University Medical Centre), Kwan‐Leung Chan(University of Ottawa), Abdallah Almaghraby(Alexandria University), Bernard Iung(Assistance Publique – Hôpitaux de Paris), Patrizio Lancellotti(University of Liège), Gilbert Habib(Aix-Marseille Université), the ESC EORP EURO-ENDO Registry Investigator Group, Roberto Ferrari, A Alonso, J. J. Bax, Carina Blomström‐Lundqvist, S. Gielen, A P Maggioni, Patrizio Lancellotti(University of Liège), N Maniadakis, Fausto J. Pinto, Frank Ruschitzka, L Tavazzi, P Vardas, F Weidinger, U Zeymer, Alec Vahanian, Andrzej Budaj, Nikolaos Dagres, Nicolas Danchin, Victoria Delgado, Jonathan Emberson, Örjan Friberg, Chris P Gale, Gr. Heyndrickx, B Iung(Assistance Publique – Hôpitaux de Paris), Sherman A. James, A P Kappetein, A P Maggioni, N Maniadakis, Kristóf Nagy, G Parati, A-S Petronio, Mikko Pietilä, E Prescott, Frank Ruschitzka, Frans Van de Werf, F Weidinger, U Zeymer, Gilbert Habib(Aix-Marseille Université), Patrizio Lancellotti(University of Liège), Bernard Cosyns, Erwan Donal, Paola Anna Erba, Gilbert Habib(Aix-Marseille Université), Bernard Iung(Assistance Publique – Hôpitaux de Paris), Aldo P. Maggioni, Bogdan A. Popescu, Bernard Prendergast, Pilar Tornos, Nora Nabila Ali Tatar-Chentir, Mouaz H. Al‐Mallah, Meriam Åström Aneq, George Athanassopoulos, Luigi P. Badano, S. Benyoussef, Erick Calderón-Aranda, Nuno Cardim, Kwan‐Leung Chan(University of Ottawa), Bernard Cosyns, Ines Cruz, Thor Edvardsen, Georg Goliasch, Gilbert Habib(Aix-Marseille Université), Andreas Hagendorff, Krasimira Hristová, Bernard Iung(Assistance Publique – Hôpitaux de Paris), Otto Kamp, Duk‐Hyun Kang, William Kong, С.Т. Мацкеплишвили, Marwa Meshaal, M Mirocevic, Aleksandar Nešković, Michal Pazderník, Edyta Płońska‐Gościniak, Bogdan A. Popescu, Bernard Prendergast, Maha Raissouni, Ricardo Ronderos, Leyla Elif Sade, Anita Sadeghpour, Antonia Sambola(Centro de Investigación en Red en Enfermedades Cardiovasculares), Shantanu P. Sengupta, Jadranka Šeparović Hanževački(University Hospital Centre Zagreb), Masaaki Takeuchi, Edwin S. Tucay, Ana Clara Tude Rodrigues, Albert Varga, Jolanta Justina Vaškelytė, Kentaro Yamagata, Kyriakos Yiangou, Hosam Zaky, Ricardo Ronderos, Gustavo Avegliano, P. Fernandez Oses, Eduardo Filipini, Isabel Granada, Ana Iribarren, M Mahia, Francisco Nacinovich, S Ressi, R Obregon, M Bangher, J Dho, Luis R Cartasegna, M. Plastino, V Novas, C Shigel, Graciela Reyes, M De Santos, Natalio Gastaldello, M Granillo Fernandez, M Potito, Gisela Streitenberger, P Velazco, José Casabé, Claudia Cortés, Eduardo Guevara, Fabián Salmo, M Seijo, F Weidinger, Maria Heger, Renee L. Brooks, Claudia Stöllberger, Carolyn Y. Ho, Leonard Perschy, L Puskas, Georg Goliasch, Christian Binder, Raphaël Rosenhek, M Schneider, M-P Winter, E Hoffer, M Melissopoulou, E Lecoq, D. Legrand, Sandrine Jacquet, M Massoz, Patrizio Lancellotti(University of Liège), Luc Piérard, Raluca Dulgheru, Stella Marchetta, Céline D'Emal, Cécile Oury, Bernard Cosyns, S Droogmans, D. Kerkhove, Andreea Motoc, D. Plein, Bram Roosens, L Soens, Caroline Weytjens, I Lemoine, Inez Rodrigus, Bernard P. Paelinck, Bram J. Amsel, Philippe Unger, Déborah Konopnicki, C. Beauloye, Agnès Pasquet, S Pierard, David Vancraeynest, Jean‐Louis Vanoverschelde, F Sinnaeve, José Lázaro Andrade, Ana Clara Tude Rodrigues, Kamila Fernanda Staszko, R Dos Santos Monteiro, Marcelo Haertel Miglioranza, D L Shuha, M Alcantara, V Cravo, L Fazzio, Ana Félix, M Iso, C Musa, Ana Paula dos Reis Velloso Siciliano, Fábio Villaça Guimarães Filho, Juarez R. Braga, Ana Clara Tude Rodrigues, R Silva, F Vilela, Daniela Laranja Gomes Rodrigues, L Silva, Samira Saady Morhy, Cláudio Henrique Fischer, R Silva, Marcelo Luiz Campos Vieira, T Afonso, J Abreu, Sandra Nívea dos Reis Saraiva Falcão, Valdir Ambrósio Moisés, Agostinho Pinto Gouvêa, G João, Francesco M. Mancuso, Carina Silva, Ana Carolina Mello Fontoura de Souza, Cely Saad Abboud, Rodrigo Bellio de Mattos Barretto, A Ramos, Renato Tambellini Arnoni, Jorge Eduardo Assef, Dorival Júlio Della Togna, David Le Bihan, L. Miglioli, A P Romero Oliveira, Roberto Tadeu Magro Kroll, Daniel Cortez, Cláudio Léo Gelape, Mara Nunes, Teresa Cristina Abreu Ferrari, KL Chan(University of Ottawa), Kevin A. Hay, V. Le, Mathieu Page, Frédéric Poulin, Claude Sauvé, Karim Serri, Chantal Mercure, J Beaudoin, Philippe Pîbarot, Igal A. Sebag, Lawrence Rudski, G Ricafort, Bruno Baršić, Vladimir Krajinović, Martina Vargović, J Separovic-Hanzevacki(University Hospital Centre Zagreb), Daniel Lovrić, V Reskovic-Luksic(University Hospital Centre Zagreb), Josip Vincelj, Sandra Jakšić Jurinjak, V Yiannikourides, Marios Ioannides, Chara Kyriakou, C Pofaides, V Masoura, K Yiangou, Jiří Pudich, Aleš Linhart, Michal Širanec, J Marek, K Blechova, Mirt Kamenik, Michal Pazderník, Radek Pelouch, Zdeněk Coufal, M Mikulica, Martin Gřiva, Eva Jančová, M Mikulcova, Miloš Táborský, Jan Přeček, Markéta Ječmenová, J Látal, J Widimský, T Butta, S Machacek, R Vancata, Jindřich Špinar, Mária Holická, F Pow Chon Long, N Anzules, Arturo Carpio, G Largacha, Ernesto Peñaherrera, Davide Moreira, E Mahfouz, E Elsafty, Ahmed M. Soliman, Yazan Zayed, J Aboulenein, M Abdel-Hay, Abdallah Almaghraby(Alexandria University), Mahmoud Abdelnaby, Mustafa I. Ahmed, Basma Hammad, Yehia Saleh, Hatice S. Zahran, O Elgebaly, Aly M A Saad, Mohammed Ali, A Zeid, Reham El Sharkawy, Marwa Meshaal, A Al Kholy, Ramy Doss, Dina Osama, Hussien Rizk, A Elmogy, M Mishriky, Patrick Assayag, Safwane El Hatimi, Élisabeth Botelho-Nevers, Saveria Campisi, J-F Fuzellier, Amandine Gagneux‐Brunon, Romain Pierrard, C. Tulane, M Detoc, T Mehalla, David Boutoille, Ousama Al Habash, N Asseray-Madani, Charlotte Biron, Julia Brochard, J. Caillon, C Cueff, Thierry Le Tourneau, Anne-Sophie Lecompte, R. Lecomte, M. Lefèbvre, M. Michel, S. Pattier, S Delarue, M. Le Bras, Jéremie Orain, J-F Faucher, Victor Aboyans, A Beeharry, H. Durox, Maximiliano Otero Lacoste, Julien Magné, Dania Mohty, Anthony S. David, V. Pradel, Victor Sierra, A. Neykova, B Bettayeb, S Elkentaoui, B. Tzvetkov, Gregory J. Landry, C. Strady, K Ainine, S. Baumard, Camille Brasselet, C Tassigny, V Valente-Pires, Marie‐Paule Lefranc, Bruno Hoen, Benjamin Lefèvre, Elodie Curlier, C Callier, N Fourcade, Yannick Jobic, S Ansard, Rozenn Le Berre, Philippe Roux, Florent Le Ven, M-C Pouliquen, Gemma Prat, F Bouchart, A. Savouré, C. Alarçon, C. Chapuzet, I. Gueït(Centre Hospitalier Universitaire Amiens-Picardie), C Tribouilloy(Centre Hospitalier Universitaire Amiens-Picardie), Y. Bohbot, Fanny Peugnet, Mesut Gun, B Iung(Assistance Publique – Hôpitaux de Paris), Xavier Duval, X. Lescure, Emila Ilic-Habensus, Nicolas Sadoul, Christine Selton‐Suty, Elodie Chevalier, François Goehringer, Olivier Huttin, R Garcia, V Le Marcis, P Tattevin, E Donal, Erwan Flécher, Matthieu Revest, Gilbert Habib(Aix-Marseille Université), S. Hubert, J-P Casalta, Frédérique Gouriet, Florent Arregle, Serge Cammilleri, Laurent Tessonnier, Alberto Ribéri, C. Chirouze, Kévin Bouiller, A-S Brunel, Pierre‐Edouard Fournier, L Hustache-Mathieu, Timothée Klopfenstein, J Moreau, Pitt Lim, Léopold Oliver, Julien Ternacle(Hôpitaux Universitaires Henri-Mondor), Amina Moussafeur, P. Chavanet, Lionel Piroth, M. Buisson, Sophie Mahy, Carolina Castro Martins, A Salmon-Rousseau, Sandrine Gohier, C. Piper, Jochen Börgermann, Denise Guckel, Dieter Horstkotte, B Brockmeier, Eliane Roseli Winkelmann, Andreas Hagendorff, Douglas Grey, Georg Nickenig, Robert Schueler, Cihat Öztürk, Elisabeth Stöhr, Christian W. Hamm, Thomas Walther, Reynaldo André Brandt, A-C Frühauf, Christine Hartung, C Hellner, C. Wild, Miriam Becker, Satoshi Hamada, W. Kaestner, Karl Stangl, Fabian Knebel, Gerd Baldenhofer, Anna Brecht, Henryk Dreger, C Isner, Frieder Pfäfflin, Miriam Stegemann, R Zahn, B. Fraiture, Caroline Kilkowski, A-K Karcher, S Klinger, H Tolksdorf, Dimitris Tousoulis, Constadina Aggeli, G. Sarri, Skevos Sideris, Erifili Venieri, George Athanassopoulos, Dimitris Tsiapras, I Armenis, A Koutsiari, G Floros, C. Grassos, Stylianos Dragasis, Lοukianos S. Rallidis, Charalampos Varlamos, Lampros K. Michalis, Katerina Κ. Naka, Aris Bechlioulis, Anna Kotsia, Λάμπρος Λάκκας, Κωνσταντίνος Παππάς, Constantinos Papadopoulos, S Kiokas, Athina Lioni, S Misailidou, John Barbetseas, Μaria Bonou, Chris J. Kapelios, I Tomprou, Kanella Zerva, Athanasios Manolis, E. Hamodraka, Dimitrios Athanasiou, G Haralambidis, L Poulimenos, H Samaras, A Nagy, Andrea Bartykowszki, Edit Gara, Shantanu P. Sengupta, Kunda Mungulmare, Ravi R. Kasliwal, Manish Bansal, A Bhan, S Ranjan, Majid Kyavar, Majid Maleki, F Noohi Bezanjani, Anita Sadeghpour, Azin Alizadehasl, Shabnam Boudagh, A Ghavidel, Pardis Moradnejad, Hamid Reza Pasha, Behshid Ghadrdoost, Dan Gilon, Jacob Strahilevitz, Sarah Israel, Maor Wanounou, Carlo D’Agostino, P Colonna, Lucrezia De Michele, F Fumarola, M Stante, N Marchionni, Valentina Scheggi, B Alterini, Stefano Del Pace, Pierluigi Stefàno, Clotilde Sparano, Luigi P. Badano, Denisa Muraru, N Ruozi, R Tenaglia, Ugo Limbruno, Alberto Cresti, Pasquale Baratta, Marco Solari, Cristina Giannattasio, Antonella Moreo, Benedetta De Chiara, Beatriz Montero, F Musca, C A Orcese, Francesca Panzeri, Claudio Russo, F. Spano, Ottavio Alfieri, Michele De Bonis, Eustachio Agricola, Elena Busnardo, Silvia Carletti, Barbara Castiglioni, Stefania Chiappetta, Benedetto Del Forno, David Ferrara, Monica Guffanti, Giuseppe Iaci, E Lapenna, Teodora Nisi, Chiara Oltolini, U. Pajoro, Renée Pasciuta, Marco Ripa, Paolo Scarpellini, Chiara Tassan Din, Roberta Meneghin, Davide Schiavi, Federico Piscione, Rodolfo Citro, Rossella Maria Benvenga, Luigi Greco, Costantina Prota, I Radano, L Soriente, Michele Bellino, Davide Di Vece, Francesco Santini, Antonio Salsano, G M Olivieri, F Turrini, R Messora, Stefano Tondi, Andreea Olaru, Virginia Agnoletto, L Grassi, Claudia Leonardi, S Sansoni, Stefano del Ponte, Guglielmo Mario Actis Dato, Andrea De Martino, Nobuyuki Ohte, Shohei Kikuchi, Kazuaki Wakami, Kazutaka Aonuma, Yu Bin Seo, Tomoko Ishizu, Tomoko Machino‐Ohtsuka, Masae Yamamoto, N Iida, Hiromichi Nakajima, Yu Nakagawa, Chisato Izumi, Masashi Amano, Makoto Miyake, Kosuke Takahashi, Ichiro Shiojima, Yoko Miyasaka, Hirofumi Maeba, Yoshinobu Suwa, Naoyuki Taniguchi, Satoshi Tsujimoto, Takeshi Kitai, Masao Ôta, Satoshi Yuda, S Sasaki, N Hagiwara, K Yamazaki, K Ashihara, K Arai, Chihiro Saitou, S Saitou, G Suzuki, Yuichi Shibata, Naoki Watanabe, Shun Nishino, Kohei Ashikaga, Nagato Kuriyama, Keitaro Mahara, Kyohei Abe, H Fujimaki, Takashi Okubo, Hidemasa Shitan, S Takanashi, M Terada, Haruko Yamamoto, Masafumi Sata, Hirotsugu Yamada, Kenya Kusunose, Yasuaki Saijo, Haruo Seno, O Yuichiro, Yukio Sakata, Hiroya Mizuno, Satoshi Nakatani, T Onishi, K. Sengoku, Francesco Sera, S W Park(Samsung Medical Center), K Eun Kyoung, L Ga Yeon, J-w Hwang, C Jin-Oh, S-J Park(Samsung Medical Center), L Sang-Chol, C Sung-A, Se Yong Jang, D-H Kang, Ran Heo, S Lee, J-M Song, E. Jung, Jurgita Plisienė, A Dambrauskaite, G Gruodyte, Regina Jonkaitienė, J Vaskelyte, Vaida Mizarienė, J Atkocaityte, Rūta Žvirblytė, Rouguiatou Sow, A. Codreanu, E Chamorro-De Vega, C. Michaux, T. Staub, L Jacobs-Orazi, C. Mallia Azzopardi, Robert G. Xuereb, T. Piscopo, David Borg, Ramon Casha, James Farrugia, M Fenech, E Pllaha, Ciro Vella, Kentaro Yamagata, L Grib, Elena Raevschi, A Grejdieru, Gheorghe G. Balan, I Cardaniuc, L Cardaniuc, V Corcea, A Feodorovici, V Gaina, L Girbu, Pavlina Jimbei, D Kravcenco, E Panfile, E Prisacari, E Samohvalov, S Samohvalov, N Sceglova, I Benesco, V Marian, N Sumarga, M Mirocevic, B Božović, Nebojša Bulatović, P Lakovic, Ljilja Musić, Jolien W. Roos‐Hesselink, Ricardo P.J. Budde, T Gamela, A Wahadat, Otto Kamp, T Meijers, Joost P. van Melle, Vincent M. van Deursen, Harry J.G.M. Crijns, S Bekkers(Maastricht University Medical Centre), Emile C. Cheriex, M Gilbers, Bas Kietselaer, Christian Knackstedt, Roberto Lorusso, Simon Schalla, S Streukens, S Chamuleau, M-J Cramer, Arco J. Teske, T Van der Spoel, A Wind, O Liesbek, J Lokhorst, H Van Heusden, Wilco Tanis, Ivo van der Bilt, Joris W.J. Vriend, H De Lange-van Bruggen, E Karijodikoro, Robert K. Riezebos, Elise van Dongen, J Schoep, V Stolk, Olivier Axler, Florian Baumann, S Lebras, Thor Edvardsen, J T Offstad, J O Beitnes, Thomas Helle-Valle, Helge Skulstad, Rita Skårdal, Nadeem Qamar, Shumaila Furnaz, Bina Ahmed, M H Butt, M F Khanzada, Tahir Saghir, A Wahid, Tomasz Hryniewiecki, Piotr Szymański, Karolina Marzec, M Misztal-Ogonowska, Wojciech Kosmala, M Przewlocka-Kosmala, Amanda Rojek, K Woznicka, J Zachwyc, A Lisowska, M. Kamińska, Jarosław D. Kasprzak, Ewelina Kowalczyk, D F Strzecka, Paulina Wejner‐Mik, M Trabulo, P Freitas, Sara Ranchordás, Gabriel Rodrigues, Patrícia Pinto, Catarina Queirós, J Azevedo, L Marques, Daniel Seabra, Luísa Moura Branco, J Abreu, Mycaella de Matos Cruz, A Galrinho, Rita Ilhão Moreira, Pedro Rio, Ana Teresa Timóteo, Mafalda Selas, Nuno Cardim, Vanda Carmelo, Bernardo Neves, Hélder Pereira, Isabel Cruz, Andrea Guerra, A Marques, I Pintassilgo, Mirela Tomescu, N-M Trofenciuc, Minodora Andor, A Bordejevic, H S Branea, Florin Alexandru Căruntu, Liviu Cirin, Ioana Mihaela Citu, Coralia Cotoraci, D Darabantiu, R Farcas, Iosif Marincu, Adelina Mavrea, M F Onel, T Parvanescu, Dana Pop, Adina Pop‐Moldovan, M I Puticiu, L A Velcean, A. Ionac, Dragoș Cozma, Cristian Mornoş, F Goanta, I Popescu, Ruxandra Beyer, Razvan O. Mada, Raluca Rancea, Ştefan Horia Roşian, Raluca Tomoaia, Cristina Stănescu, Zhanna Kobalava, J Karaulova, E. O. Kotova, A Milto, A Pisaryuk, N Povalyaev, Maria Sorokina, Jamilah AlRahimi, A Elshiekh, A Jamiel, Ali Ahmed, Mouaz H. Al‐Mallah, N. Attia, B Putnikovic, Aleksandar Nešković, Andreja Dimić, Branislava Ivanović, S Matić, D Trifunovic, Jelena Petrović, D Kosevic, P Dabic, Predrag Milojević, Ivana Petrović, Ivana Stojanović, Ilija Srdanović, M Kovacević, Aleksandar Redžek, Maja Stefanović, S Susak, Lazar Velicki, Aleksandra Vulin, Tiong Cheng Yeo, Feng Kong, Kian Keong Poh, Isidre Vilacosta, M Abd El- Nasser, C Ferrera, Carmen Olmos(Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Francisco Calvo, E Blanco-Gonzalez, M Bravo Amaro, A. Nodar Germiñas, E Lopez-Rodriguez, J Lugo Adan, P Pazos-Lopez, M Pereira Loureiro, Maria T. Perez, Sergio Raposeiras‐Roubín, S Rasheed Yas, M-M Suarez-Varela, F Vasallo Vidal, David García‐Dorado, Antonia Sambola(Centro de Investigación en Red en Enfermedades Cardiovasculares), Nuria Fernández‐Hidalgo, Teresa González‐Alujas, J Lozano, Olga Maisterra, Natalia Pizzi, R Rios, P. Tornos, Antoni Bayés‐Genís, L Pedro Botet, Núria Vallejo, E. Berastegui, C Llibre, Lourdes Mateu, R Nunez, D Quesada, D Bosch Portell, J Aboal Vinas, X Bertrán, R Brugada Tarradellas, P Loma-Osorio Ricon, C Tiron de Llano, Miguel Á. Arnau, A. Bel, Marino Blanes, A. Osa, M Anguita, Fernando Carrasco, Juan C. Castillo, José Luis Zamorano, José Luis Moya Mur, M Alvaro, Covadonga Fernández‐Golfín, J M Monteagudo, Enrique Navas, MICHELLE CARRASQUEL ALVAREZ, J Agüero Balbín, Carlos Armiñanzas, F Arnaiz de las Revillas, A Arnaiz Garcia, Manuel Cobo Belaustegui, Marta Fernández Sampedro, Manuel Cuadra, J.F. Gutiérrez-Díez, Jesús Zarauza, L García Cuello, Claudia González-Rico, Regino Rodríguez, Josune Goikoetxea, M Montejo, José M. Miró, Manel Almela, Juan Ambrosioni, Carlos Falces, David Fuster, C Garcia-de-la-Maria, Marta Hernández‐Meneses, J Llopis, Francesc Marco, A. Moreno, Eduard Quintana, Elena Sandoval, A Tellez, J M Tolosana, Begoña Alcaraz Vidal, Isabel Ruíz-Zamora, A Bardaji Ruiz, E. Sanz, G Garcia-Pardo, M Guillen Marzo, A Rodriguez Oviedo, A Villares Jimenez, Leïla Abid, Rania Hammami, S. Kammoun, Mohamed Sami Mourali, F Mghaieth Zghal, Manel Ben Hlima, S. Boudiche, S. Ouali, Lilia Zakhama, S Antit, I. Ben Slama, Okan Gülel, Müjgan Ayşenur Şahin, Leyla Elif Sade, Emir Karaçağlar, S Kucukoglu, Özge Çetinarslan, U S Yasar, Uğur Canpolat, Bülent Mutlu, Hakan Ataş, R Dervishova, Çiğdem İleri, H Zaky, J Alhashmi, F Baslib, J Tahir, P Zarger, Simon Woldman, Leon Menezes, C Primus, Rakesh Uppal, I Bvekerwa, Badrinathan Chandrasekaran, A Kopanska, Bernard Prendergast, Stefano Cannata, John B. Chambers, Jane Hancock, John L. Klein, Ronak Rajani, Maria Paola Ursi, Rafał Dworakowski, A Fife, John Breeze, M Browne-Morgan, M. Gunning, S Streather, Federico M. Asch, M Zemedkun, B. A. Alyavi, Jamol Uzokov
Cited by 40Open Access
Abstract
BACKGROUND AND AIMS: Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. METHODS: The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016-18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. RESULTS: There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13-1.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54-2.33, P < .0001), history of heart failure (HR 1.53, 95% CI 1.21-1.93, P = .0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25-2.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08-1.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12-1.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08-6.79, P < .0001), alcohol abuse (HR 1.45, 95% CI 1.04-2.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29-3.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05-1.61, P = .016) (C-statistic = .68). CONCLUSIONS: Prognosis after LSIE is determined by multiple factors, including vegetation size.
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