Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma

Yuan Zhou(Shanghai Medical College of Fudan University), Li Zhang(Shanghai Medical College of Fudan University), Yue Ma(Shanghai Medical College of Fudan University), Li Xie(Shanghai Medical College of Fudan University), Yang Yong-yu(Shanghai Medical College of Fudan University), Jin Cheng(Shanghai Medical College of Fudan University), Hui Chen(Shanghai Medical College of Fudan University), Ying Zhou(Shanghai Medical College of Fudan University), Guangqi Song(Suzhou University of Science and Technology), Jia Ding(Jinshan Hospital of Fudan University), Jian Wu(Shanghai Medical College of Fudan University)
Theranostics
January 1, 2023
10.7150/thno.85369
Cited by 27Open Access
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Abstract

Senescent HSCs secreted a characterized protein profile favoring malignant transformation of steatotic or dysplastic hepatocytes through activating morphogenic hedgehog or oncogenic Wnt signaling pathways in the progression from NASH to malignancy.

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