Organ Mapping Antibody Panels: a community resource for standardized multiplexed tissue imaging
Ellen M. Quardokus(Indiana University Bloomington), Diane C. Saunders(Vanderbilt University), Elizabeth McDonough(GE Global Research (United States)), John W. Hickey(Stanford University), Christopher Werlein(Medizinische Hochschule Hannover), Christine Surrette(GE Global Research (United States)), Presha Rajbhandari(Columbia University), Anna Martinez Casals(Science for Life Laboratory), Hua Tian(Pennsylvania State University), Lisa Lowery(GE Global Research (United States)), Elizabeth K. Neumann(Vanderbilt University), Frida Björklund(Science for Life Laboratory), Taruna V. Neelakantan(Columbia University), Joshua Croteau(BioLegend (United States)), Anne E. Wiblin(Abcam (United Kingdom)), Jeremy Fisher(Cell Signaling Technology (United States)), April J. Livengood(Thermo Fisher Scientific (United States)), Karen Dowell(Akoya Biosciences (United States)), Jonathan C. Silverstein(University of Pittsburgh), Jeffrey M. Spraggins(Vanderbilt University), Gloria Pryhuber(University of Rochester Medical Center), Gail Deutsch(University of Washington Medical Center), Fiona Ginty(GE Global Research (United States)), Garry P. Nolan(Stanford University), Simon Melov(Buck Institute for Research on Aging), Danny Jonigk(Medizinische Hochschule Hannover), Michael A. Caldwell(Northwestern University), Ioannis S. Vlachos(Broad Institute), Werner Müller(Miltenyi Biotec (Germany)), Nils Gehlenborg(Harvard University), Brent R. Stockwell(Columbia University), Emma Lundberg(Science for Life Laboratory), M Snyder(Stanford University), Ronald N. Germain(Advanced Tissue (United States)), Jeannie M. Camarillo(Northwestern University), Neil L. Kelleher(Northwestern University), Katy Börner(Indiana University Bloomington), Andrea J. Radtke(Office of Extramural Research)
Cited by 44Open Access
Abstract
Multiplexed antibody-based imaging enables the detailed characterization of molecular and cellular organization in tissues. Advances in the field now allow high-parameter data collection (>60 targets); however, considerable expertise and capital are needed to construct the antibody panels employed by these methods. Organ mapping antibody panels are community-validated resources that save time and money, increase reproducibility, accelerate discovery and support the construction of a Human Reference Atlas.
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