The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Daniela Brina; Adele Ponzoni; Martina Troiani; Bianca Calì; Emiliano Pasquini; Giuseppe Attanasio; Simone Mosole; Michela Mirenda; Mariantonietta D’Ambrosio; Manuel Colucci; Ilaria Guccini; Ajinkya Revandkar; Abdullah Alajati; Toma Tebaldi; Deborah Donzel; Fabio Lauria; Nahjme Parhizgari; Aurora Valdata; Martino Maddalena; Arianna Calcinotto; Marco Bolis; Andrea Rinaldi; Simon T. Barry; Jan H. Rüschoff; Marianna Sabbadin; Semini Sumanasuriya; Mateus Crespo; Adam Sharp; Wei Yuan; Mathew Grinu; Alexandra Boyle; Cynthia L. Miller; Lloyd C. Trotman; Nicolas Delaleu; Matteo Fassan; Holger Moch; Gabriella Viero; Johann S. de Bono; Andrea Alimonti

doi:10.1038/s43018-023-00594-z

The Akt/mTOR and MNK/eIF4E pathways rewire the prostate cancer translatome to secrete HGF, SPP1 and BGN and recruit suppressive myeloid cells

Daniela Brina(Institute of Oncology Research), Adele Ponzoni(490 BioTech (United States)), Martina Troiani(Institute of Oncology Research), Bianca Calì(Institute of Oncology Research), Emiliano Pasquini(Institute of Oncology Research), Giuseppe Attanasio(Institute of Oncology Research), Simone Mosole(Institute of Oncology Research), Michela Mirenda(Institute of Oncology Research), Mariantonietta D’Ambrosio(Institute of Oncology Research), Manuel Colucci(Institute of Oncology Research), Ilaria Guccini(ETH Zurich), Ajinkya Revandkar(Harvard University), Abdullah Alajati(University Hospital Bonn), Toma Tebaldi(Yale Cancer Center), Deborah Donzel, Fabio Lauria, Nahjme Parhizgari(Biocon (Switzerland)), Aurora Valdata(Institute of Oncology Research), Martino Maddalena(Institute of Oncology Research), Arianna Calcinotto(Institute of Oncology Research), Marco Bolis(SIB Swiss Institute of Bioinformatics), Andrea Rinaldi(Institute of Oncology Research), Simon T. Barry(AstraZeneca (United Kingdom)), Jan H. Rüschoff(University Hospital of Zurich), Marianna Sabbadin(Istituto Oncologico Veneto), Semini Sumanasuriya(Royal Marsden NHS Foundation Trust), Mateus Crespo(Royal Marsden NHS Foundation Trust), Adam Sharp(Royal Marsden NHS Foundation Trust), Wei Yuan(Royal Marsden NHS Foundation Trust), Mathew Grinu(Cold Spring Harbor Laboratory), Alexandra Boyle(Cold Spring Harbor Laboratory), Cynthia L. Miller(Cold Spring Harbor Laboratory), Lloyd C. Trotman(Cold Spring Harbor Laboratory), Nicolas Delaleu, Matteo Fassan(University of Padua), Holger Moch(University Hospital of Zurich), Gabriella Viero, Johann S. de Bono(Royal Marsden NHS Foundation Trust), Andrea Alimonti(Board of the Swiss Federal Institutes of Technology)

Nature Cancer

July 17, 2023

10.1038/s43018-023-00594-z

Cited by 62Open Access

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