The NLRP3 inflammasome: contributions to inflammation-related diseases

Ying Chen(First Affiliated Hospital of Xi'an Jiaotong University), Xingyan Ye(Ministry of Education of the People's Republic of China), Germaine Escames(Universidad de Granada), Wangrui Lei(Ministry of Education of the People's Republic of China), Xin Zhang(Yan'an University), Meng Li(Yan'an University), Tong Jing(Yan'an University), Yu Yao(Ministry of Education of the People's Republic of China), Zhenye Qiu(Ministry of Education of the People's Republic of China), Zheng Wang(Chinese People's Liberation Army), Darı́o Acuña-Castroviejo(Universidad de Granada), Yang Yang(Ministry of Education of the People's Republic of China)
Cellular & Molecular Biology Letters
June 27, 2023
10.1186/s11658-023-00462-9
Cited by 374Open Access
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Abstract

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates innate immune responses by activating caspase-1 and the inflammatory cytokines interleukin (IL)-1β and IL-18. Multiple studies have demonstrated the importance of the NLRP3 inflammasome in the development of immune and inflammation-related diseases, including arthritis, Alzheimer's disease, inflammatory bowel disease, and other autoimmune and autoinflammatory diseases. This review first explains the activation and regulatory mechanism of the NLRP3 inflammasome. Secondly, we focus on the role of the NLRP3 inflammasome in various inflammation-related diseases. Finally, we look forward to new methods for targeting the NLRP3 inflammasome to treat inflammation-related diseases, and provide new ideas for clinical treatment.

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