Alcohol consumption and risks of more than 200 diseases in Chinese men

Pek Kei Im; Neil Wright; Ling Yang; Ka Hung Chan; Yiping Chen; Yu Guo; Huaidong Du; Xiaoming Yang; Daniel Avery; Shaojie Wang; Canqing Yu; Jun Lv; Robert Clarke; Junshi Chen; Rory Collins; Robin Walters; Richard Peto; Liming Li; Zhengming Chen; Iona Y. Millwood; China Kadoorie Biobank Collaborative Group; Chen Wang; Maxim Barnard; Derrick Bennett; Ruth Boxall; Johnathan Clarke; Ahmed Edris Mohamed; Hannah Fry; Simon Gilbert; Andri Iona; Maria Kakkoura; Christiana Kartsonaki; Hubert Lam; Kuang Lin; James H. Liu; Mohsen Mazidi; Sam Morris; Qunhua Nie; Alfred Pozarickij; Paul Ryder; Saredo Said; Dan Schmidt; Becky Stevens; Iain Turnbull; Baihan Wang; Lin Wang; Pang Yao; Xiao Han; Can Hou; Qingmei Xia; Chao Liu; Pei Pei; Dianjianyi Sun; Naying Chen; Duo Liu; Zhenzhu Tang; Ningyu Chen; Qilian Jiang; Jian Lan; Mingqiang Li; Yun Liu; Fanwen Meng; Jinhuai Meng; Rong Pan; Yulu Qin; Ping Wang; Sisi Wang; Liuping Wei; Liyuan Zhou; Caixia Dong; Pengfei Ge; Xiaolan Ren; Zhongxiao Li; Enke Mao; Tao Wang; Hui Zhang; Xi Zhang; Jinyan Chen; Ximin Hu; Xiaohuan Wang; Zhendong Guo; Huimei Li; Yilei Li; Min Weng; Shukuan Wu; Shichun Yan; Mingyuan Zou; Xue Zhou; Ziyan Guo; Quan Kang; Yanjie Li; Bo Yu; Qinai Xu; Liang Chang; Lei Fan; Shixian Feng; Ding Zhang; Gang Zhou; Yulian Gao; Tianyou He; Pan He; Chen Hu; Huarong Sun; Xukui Zhang; Biyun Chen; Zhongxi Fu; Yuelong Huang; Huilin Liu; Qiaohua Xu; Yin Li; Huajun Long; Xin Xu; Hao Zhang; Libo Zhang; Jian Su; Ran Tao; Ming Wu; Jie Yang; Jinyi Zhou; Yonglin Zhou; Yihe Hu; Yujie Hua; Jianrong Jin; Fang Liu; Jingchao Liu; Yan Lu; Liangcai Ma; Aiyu Tang; Jun Zhang; Liang Cheng; Huaidong Du; Ruqin Gao; Feifei Li; Shanpeng Li; Yongmei Liu; Feng Ning; Zengchang Pang; Xiaohui Sun; Xiaocao Tian; Yaoming Zhai; Hua Zhang; Wei Hou; Jun Lv; Junzheng Wang; Xiaofang Chen; Xianping Wu; Ningmei Zhang; Xiaoyu Chang; Xiaofang Chen; Jianguo Li; Jiaqiu Liu; Guojin Luo; Qiang Sun; Xunfu Zhong; Weiwei Gong; Ruying Hu; Hao Wang; Meng Wang; Min Yu; Lingli Chen; Qijun Gu; Dongxia Pan; Chunmei Wang; Kaixu Xie; Xiaoyi Zhang

doi:10.1038/s41591-023-02383-8

Alcohol consumption and risks of more than 200 diseases in Chinese men

Pek Kei Im(University of Oxford), Neil Wright(University of Oxford), Ling Yang(University of Oxford), Ka Hung Chan(University of Oxford), Yiping Chen(University of Oxford), Yu Guo(Chinese Academy of Medical Sciences & Peking Union Medical College), Huaidong Du(University of Oxford), Xiaoming Yang(University of Oxford), Daniel Avery(University of Oxford), Shaojie Wang(Qingdao Municipal Center for Disease Control and Prevention), Canqing Yu(Peking University), Jun Lv(Peking University), Robert Clarke(University of Oxford), Junshi Chen(China National Center for Food Safety Risk Assessment), Rory Collins(University of Oxford), Robin Walters(University of Oxford), Richard Peto(University of Oxford), Liming Li(Peking University), Zhengming Chen(University of Oxford), Iona Y. Millwood(University of Oxford), China Kadoorie Biobank Collaborative Group(China-Japan Friendship Hospital), Chen Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Maxim Barnard(University of Oxford), Derrick Bennett(University of Oxford), Ruth Boxall(University of Oxford), Johnathan Clarke(University of Oxford), Ahmed Edris Mohamed(University of Oxford), Hannah Fry(University of Oxford), Simon Gilbert(University of Oxford), Andri Iona(University of Oxford), Maria Kakkoura(University of Oxford), Christiana Kartsonaki(University of Oxford), Hubert Lam(University of Oxford), Kuang Lin(University of Oxford), James H. Liu(University of Oxford), Mohsen Mazidi(University of Oxford), Sam Morris(University of Oxford), Qunhua Nie(University of Oxford), Alfred Pozarickij(University of Oxford), Paul Ryder(University of Oxford), Saredo Said(University of Oxford), Dan Schmidt(University of Oxford), Becky Stevens(University of Oxford), Iain Turnbull(University of Oxford), Baihan Wang(University of Oxford), Lin Wang(University of Oxford), Pang Yao(Peking University), Xiao Han(Peking University), Can Hou(Peking University), Qingmei Xia(Peking University), Chao Liu(Peking University), Pei Pei(Peking University), Dianjianyi Sun(Peking University), Naying Chen(Liu Zhou Center for Disease Prevention and Control), Duo Liu(Guangxi Center for Disease Prevention and Control), Zhenzhu Tang(Liu Zhou Center for Disease Prevention and Control), Ningyu Chen(Liu Zhou Center for Disease Prevention and Control), Qilian Jiang(Liu Zhou Center for Disease Prevention and Control), Jian Lan(Liu Zhou Center for Disease Prevention and Control), Mingqiang Li(Liu Zhou Center for Disease Prevention and Control), Yun Liu(Liu Zhou Center for Disease Prevention and Control), Fanwen Meng(Liu Zhou Center for Disease Prevention and Control), Jinhuai Meng(Liu Zhou Center for Disease Prevention and Control), Rong Pan(Liu Zhou Center for Disease Prevention and Control), Yulu Qin(Liu Zhou Center for Disease Prevention and Control), Ping Wang(Liu Zhou Center for Disease Prevention and Control), Sisi Wang(Liu Zhou Center for Disease Prevention and Control), Liuping Wei(Liu Zhou Center for Disease Prevention and Control), Liyuan Zhou(Liu Zhou Center for Disease Prevention and Control), Caixia Dong(Gansu Provincial Center for Disease Control and Prevention), Pengfei Ge(Gansu Provincial Center for Disease Control and Prevention), Xiaolan Ren(Gansu Provincial Center for Disease Control and Prevention), Zhongxiao Li, Enke Mao, Tao Wang, Hui Zhang(Qingdao Municipal Center for Disease Control and Prevention), Xi Zhang(Xian Center for Disease Control and Prevention), Jinyan Chen(Hainan Center for Disease Control & Prevention), Ximin Hu(Hainan Center for Disease Control & Prevention), Xiaohuan Wang(Hainan Center for Disease Control & Prevention), Zhendong Guo, Huimei Li, Yilei Li, Min Weng, Shukuan Wu, Shichun Yan, Mingyuan Zou, Xue Zhou, Ziyan Guo, Quan Kang, Yanjie Li, Bo Yu, Qinai Xu(Hunan Provincial Center for Disease Control and Prevention), Liang Chang(Henan Provincial Center for Disease Control and Prevention), Lei Fan(Henan Provincial Center for Disease Control and Prevention), Shixian Feng(Henan Provincial Center for Disease Control and Prevention), Ding Zhang(Henan Provincial Center for Disease Control and Prevention), Gang Zhou(Xian Center for Disease Control and Prevention), Yulian Gao(Xian Center for Disease Control and Prevention), Tianyou He(Xian Center for Disease Control and Prevention), Pan He(Xian Center for Disease Control and Prevention), Chen Hu(Xian Center for Disease Control and Prevention), Huarong Sun(Xian Center for Disease Control and Prevention), Xukui Zhang(Hunan Provincial Center for Disease Control and Prevention), Biyun Chen(Hunan Provincial Center for Disease Control and Prevention), Zhongxi Fu(Hunan Provincial Center for Disease Control and Prevention), Yuelong Huang(Hunan Provincial Center for Disease Control and Prevention), Huilin Liu(Hunan Provincial Center for Disease Control and Prevention), Qiaohua Xu(Hunan Provincial Center for Disease Control and Prevention), Yin Li(Hunan Provincial Center for Disease Control and Prevention), Huajun Long, Xin Xu, Hao Zhang(Qingdao Municipal Center for Disease Control and Prevention), Libo Zhang(Jiangsu Provincial Center for Disease Control and Prevention), Jian Su(Jiangsu Provincial Center for Disease Control and Prevention), Ran Tao(Jiangsu Provincial Center for Disease Control and Prevention), Ming Wu(Jiangsu Provincial Center for Disease Control and Prevention), Jie Yang(Jiangsu Provincial Center for Disease Control and Prevention), Jinyi Zhou(Jiangsu Provincial Center for Disease Control and Prevention), Yonglin Zhou(Jiangsu Provincial Center for Disease Control and Prevention), Yihe Hu, Yujie Hua, Jianrong Jin, Fang Liu, Jingchao Liu(University of Oxford), Yan Lu, Liangcai Ma, Aiyu Tang, Jun Zhang(Qingdao Municipal Center for Disease Control and Prevention), Liang Cheng(Qingdao Municipal Center for Disease Control and Prevention), Huaidong Du(Qingdao Municipal Center for Disease Control and Prevention), Ruqin Gao(Qingdao Municipal Center for Disease Control and Prevention), Feifei Li(Qingdao Municipal Center for Disease Control and Prevention), Shanpeng Li(Qingdao Municipal Center for Disease Control and Prevention), Yongmei Liu(Liu Zhou Center for Disease Prevention and Control), Feng Ning(Qingdao Municipal Center for Disease Control and Prevention), Zengchang Pang(Qingdao Municipal Center for Disease Control and Prevention), Xiaohui Sun(Qingdao Municipal Center for Disease Control and Prevention), Xiaocao Tian(Qingdao Municipal Center for Disease Control and Prevention), Yaoming Zhai(Qingdao Municipal Center for Disease Control and Prevention), Hua Zhang(Qingdao Municipal Center for Disease Control and Prevention), Wei Hou, Jun Lv, Junzheng Wang(Sichuan Center for Disease Control and Prevention), Xiaofang Chen(Chengdu Center for Disease Control and Prevention), Xianping Wu(Sichuan Center for Disease Control and Prevention), Ningmei Zhang(Sichuan Center for Disease Control and Prevention), Xiaoyu Chang(Sichuan Center for Disease Control and Prevention), Xiaofang Chen(Chengdu Center for Disease Control and Prevention), Jianguo Li(Chengdu Center for Disease Control and Prevention), Jiaqiu Liu(University of Oxford), Guojin Luo(Chengdu Center for Disease Control and Prevention), Qiang Sun(Chengdu Center for Disease Control and Prevention), Xunfu Zhong(Chengdu Center for Disease Control and Prevention), Weiwei Gong(Zhejiang Center for Disease Control and Prevention), Ruying Hu(Zhejiang Center for Disease Control and Prevention), Hao Wang(Zhejiang Center for Disease Control and Prevention), Meng Wang(Zhejiang Center for Disease Control and Prevention), Min Yu(Xian Center for Disease Control and Prevention), Lingli Chen(Xian Center for Disease Control and Prevention), Qijun Gu(Xian Center for Disease Control and Prevention), Dongxia Pan(Xian Center for Disease Control and Prevention), Chunmei Wang(Chinese Academy of Medical Sciences & Peking Union Medical College), Kaixu Xie(Xian Center for Disease Control and Prevention), Xiaoyi Zhang(Xian Center for Disease Control and Prevention)

Nature Medicine

June 1, 2023

10.1038/s41591-023-02383-8

Cited by 176Open Access

Full Text

Abstract

Alcohol consumption accounts for ~3 million annual deaths worldwide, but uncertainty persists about its relationships with many diseases. We investigated the associations of alcohol consumption with 207 diseases in the 12-year China Kadoorie Biobank of >512,000 adults (41% men), including 168,050 genotyped for ALDH2- rs671 and ADH1B- rs1229984 , with >1.1 million ICD-10 coded hospitalized events. At baseline, 33% of men drank alcohol regularly. Among men, alcohol intake was positively associated with 61 diseases, including 33 not defined by the World Health Organization as alcohol-related, such as cataract (n = 2,028; hazard ratio 1.21; 95% confidence interval 1.09-1.33, per 280 g per week) and gout (n = 402; 1.57, 1.33-1.86). Genotype-predicted mean alcohol intake was positively associated with established (n = 28,564; 1.14, 1.09-1.20) and new alcohol-associated (n = 16,138; 1.06, 1.01-1.12) diseases, and with specific diseases such as liver cirrhosis (n = 499; 2.30, 1.58-3.35), stroke (n = 12,176; 1.38, 1.27-1.49) and gout (n = 338; 2.33, 1.49-3.62), but not ischemic heart disease (n = 8,408; 1.04, 0.94-1.14). Among women, 2% drank alcohol resulting in low power to assess associations of self-reported alcohol intake with disease risks, but genetic findings in women suggested the excess male risks were not due to pleiotropic genotypic effects. Among Chinese men, alcohol consumption increased multiple disease risks, highlighting the need to strengthen preventive measures to reduce alcohol intake.

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