Reduced Staphylococcus Abundance Characterizes the Lesional Microbiome of Actinic Keratosis Patients after Field-Directed Therapies
Jan Kehrmann(University of Duisburg-Essen), Fiona Koch(Düsseldorf University Hospital), Skrollan Zumdick(University of Duisburg-Essen), Anna Höwner(Düsseldorf University Hospital), Lara Best(University of Duisburg-Essen), Lars Maßhöfer(University of Duisburg-Essen), Sarah Scharfenberg(Düsseldorf University Hospital), Michael Zeschnigk(University of Duisburg-Essen), Jürgen C. Becker(German Cancer Research Center), Dirk Schadendorf(German Cancer Research Center), Jan Buer(University of Duisburg-Essen), Alexander Roesch(German Cancer Research Center)
Cited by 9Open Access
Abstract
abundance was a feature of patients classified as responders at the end of CAP-treatment period (week 24) compared with nonresponders and the Staphylococcus aureus abundance of patients classified as responders 3 months after treatment completion was significantly lower than in nonresponders. The alterations of the skin microbiome upon AK treatment encourage further investigations for establishing its role for carcinogenesis and its function as predictive biomarker in AK.
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