Conformational dynamics of the μ-opioid receptor determine ligand intrinsic efficacy

Jiawei Zhao(Guilin Medical University), Chunlai Chen(Tsinghua University), Wayne L. Hubbell(University of California, Los Angeles), Evan S. O’Brien(Stanford University), Brian K. Kobilka(Stanford University), Jie Heng(Center for Life Sciences), Tao Che(Cleveland Research (United States)), Cecı́lia P. Sár(University of Pecs), Xiaoou Sun(Beijing Advanced Sciences and Innovation Center), Amal EI Daibani(Washington University in St. Louis), Matthias Elgeti(University of California, Los Angeles)
bioRxiv (Cold Spring Harbor Laboratory)
April 29, 2023
10.1101/2023.04.28.538657
Cited by 7

Related Papers

Crystal structure of the β2 adrenergic receptor–Gs protein complex
|Nature|2011|3k
Structure and function of an irreversible agonist-β2 adrenoceptor complex
|Nature|2011|773
Assembly of a GPCR-G Protein Complex
|Cell|2019|239
Ligand-regulated oligomerization of β2-adrenoceptors in a model lipid bilayer
|The EMBO Journal|2009|175
Structural basis of odor sensing by insect heteromeric odorant receptors
|Science|2024|122