Supplementary Table S5 from The Genetic Landscape of Clinical Resistance to RAF Inhibition in Metastatic Melanoma

Abstract

<p>XLSX file 13K, Supplementary Table S5. PI3K pathway alterations. This table provides additional details on the PI3K pathway alterations observed in this cohort. Additional information regarding the time point, protein change, and appropriate reference are provided. Biopsy time point entries in gray denote situations where the tumor was unavailable for sequencing. Allelic fractions in bold denote situations where there is evidence for loss of the alternate allele between time points. (PMID = PubMed identification number). For activating or inactivating alterations, predicted function was derived by review of the published literature. The "likely" designation was reserved for alterations that occurred at the same amino acid residue as reported events but involved different changes at that site. For remaining missense mutations, "Probably Damaging" and "Possibly Damaging" designations were obtained from PolyPhen2 in silico predictions; alterations that met that criteria had PolyPhen2 scores between 0.9 and 1. Remaining nonsense mutations were considered "Probably Damaging"</p>