BLADDER CANCER CLINICAL GUIDELINES PANEL SUMMARY REPORT ON THE MANAGEMENT OF NONMUSCLE INVASIVE BLADDER CANCER (STAGES Ta, T1 AND TIS)

The Journal of Urology
November 1, 1999
Cited by 190

Abstract

No AccessJournal of UrologyCLINICAL UROLOGY: Special Communications1 Nov 1999BLADDER CANCER CLINICAL GUIDELINES PANEL SUMMARY REPORT ON THE MANAGEMENT OF NONMUSCLE INVASIVE BLADDER CANCER (STAGES Ta, T1 AND TIS) JOSEPH A. SMITH, RICHARD F. LABASKY, ABRAHAM T.K. COCKETT, JOHN A. FRACCHIA, JAMES E. MONTIE, and RANDALL G. ROWLAND JOSEPH A. SMITHJOSEPH A. SMITH , RICHARD F. LABASKYRICHARD F. LABASKY , ABRAHAM T.K. COCKETTABRAHAM T.K. COCKETT , JOHN A. FRACCHIAJOHN A. FRACCHIA , JAMES E. MONTIEJAMES E. MONTIE , and RANDALL G. ROWLANDRANDALL G. ROWLAND View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)68208-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The American Urological Association convened the Bladder Cancer Clinical Guidelines Panel to analyze the literature regarding available methods of treating nonmuscle invasive bladder cancer, and to make practice policy recommendations based primarily on treatment outcomes data. Materials and Methods: The panel searched the MEDLINE database for all articles related to nonmuscle invasive bladder cancer published from 1966 to January 1998. Outcomes data were extracted from articles accepted after panel review and meta-analyzed to produce comparative probability estimates for alternative treatments. Results: All of the intravesical agents (thiotepa, bacillus Calmette-Guerin, mitomycin C and doxorubicin) when used as adjuvant therapy after transurethral resection resulted in a lower probability of recurrence compared to resection alone. However, there is no evidence that intravesical therapy affects long-term progression. Conclusions: For patients with no prior intravesical therapy adjuvant intravesical chemotherapy or immunotherapy is a treatment option after endoscopic removal of low grade Ta bladder cancers. Intravesical instillation of bacillus Calmette-Guerin or mitomycin C is recommended for carcinoma in situ, and after endoscopic removal of T1 and high grade Ta tumors. References 1 Smith, J. A., Labasky, R. F., Cockett, A. T. K., Fracchia, J. A., Montie, J. E. and Rowland, R. G.: Bladder Cancer Clinical Guidelines Panel: Report on the Management of Non-Muscle-Invasive Bladder Cancer (Stages Ta, T1 and Tis). Baltimore: American Urological Association, Inc., 1999. 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Volume 162Issue 5November 1999Page: 1697-1701 Advertisement Copyright & Permissions© 1999 by American Urological Association, Inc.Keywordsbladder neoplasmsimmunotherapychemotherapy, adjuvantendoscopycarcinoma, transitional cellMetricsAuthor Information JOSEPH A. SMITH More articles by this author RICHARD F. LABASKY More articles by this author ABRAHAM T.K. COCKETT More articles by this author JOHN A. FRACCHIA More articles by this author JAMES E. MONTIE More articles by this author RANDALL G. ROWLAND More articles by this author Expand All Advertisement PDF downloadLoading ...


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