Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Carina B. Nava Lauson(Istituti di Ricovero e Cura a Carattere Scientifico), Silvia Tiberti(Istituti di Ricovero e Cura a Carattere Scientifico), Paola Antonia Corsetto(University of Milan), Federica Conte(National Research Council), Punit Tyagi(Istituti di Ricovero e Cura a Carattere Scientifico), Markus Machwirth(Universitätsklinikum Würzburg), Stefan Ebert(Universitätsklinikum Würzburg), Alessia Loffreda(Vita-Salute San Raffaele University), Lukas Scheller(Universitätsklinikum Würzburg), Dalia Sheta(Universitätsklinikum Würzburg), Zeinab Mokhtari(Universitätsklinikum Würzburg), Timo Peters(Medical University of Vienna), Ayush T. Raman(Broad Institute), Francesco Greco(Scuola Superiore Sant'Anna), Angela Maria Rizzo(Universitätsklinikum Würzburg), Andreas Beilhack(Universitätsklinikum Würzburg), Giovanni Signore(Fondazione Pisa), Nicola Tumino(Bambino Gesù Children's Hospital), Paola Vacca(Bambino Gesù Children's Hospital), Liam A. McDonnell(Fondazione Pisa), Andrea Raimondi(Vita-Salute San Raffaele University), Philip D. Greenberg(Fred Hutch Cancer Center), Johannes B. Huppa(Medical University of Vienna), Simone Cardaci(Vita-Salute San Raffaele University), Ignazio Caruana(Universitätsklinikum Würzburg), Simona Rodighiero(Istituti di Ricovero e Cura a Carattere Scientifico), Luigi Nezi(Istituti di Ricovero e Cura a Carattere Scientifico), Teresa Manzo(Istituti di Ricovero e Cura a Carattere Scientifico)
Cited by 274Open Access
Abstract
Nava-Lauson et al. report that linoleic acid potentiates antitumor function of CD8+ T cells by operating a profound metabolic reprogramming that protects from exhaustion and pushes toward a memory phenotype with superior cytotoxic functions. LA-redirected CD8+ T cells are empowered with an improved metabolic and functional fitness within the TME, thereby improving efficacy of ACT-based therapy.
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