A Gene Map of the Human Genome

Greg Schuler, Mark S. Boguski, Elizabeth A. Stewart, Lincoln Stein, Gàbor Gyapay, Kate Rice, Robert E. White, Patricia Rodriguez‐Tomé, Amita Aggarwal, E. Bajorek, S Bentolila, B. B. Birren, Adam P. Butler, Andrew B. Castle, Nuchanard Chiannilkulchai, Angela Chu, C. Clee, Sid Cowles, Philip J. Day, Thomas Dibling, Nathalie Drouot, Ian Dunham, Simone Duprat, C. East, Cathryn Edwards, Jie Fan, N. Fang, Cécile Fizames, C. Garrett, L. Green, David Hadley, Mark Harris, Pat Heslop Harrison, Shannon D. Brady, Andrew A. Hicks, Eric Holloway, Lester Hui, S. Hussain, Christine Louis-Dit-Sully, Junli Ma, A. MacGilvery, Chris Mader, A. Maratukulam, Tara C. Matise, Kathleen B. McKusick, J Morissette, Andrew J. Mungall, Delphine Muselet, H. C. Nusbaum, David C. Page, A. I. Peck, S. Perkins, Mark Piercy, Fawn Qin, John Quackenbush, S. A. Ranby, Tim Reif, Steve Rozen, C. Sanders, X. She, J. Silva, Donna K. Slonim, Cari Soderlund, Wei Sun, P. Tabar, T. Thangarajah, Nathalie Vega-Czarny, Douglas Vollrath, S. Voyticky, T. E. Wilmer, Xiaoyun Wu, Mark D. Adams, Charles Auffray, Nicole A. R. Walter, Rhonda Brandon, Anindya Dehejia, Peter N. Goodfellow, Rémi Houlgatte, J. R. Hudson, Susan Ide, K. R. Iorio, W. Y. Lee, Naohiko Seki, Takahiro Nagase, Kenichi L. Ishikawa, Nobuhiko Nomura, Carolyn S. Phillips, Mihael H. Polymeropoulos, Mina Sandusky, Karin Schmitt, Rebecca Berry, Karl Swanson, Rosarelis Torres, J. Craig Venter, James M. Sikela, J. Beckmann, J. Weissenbach, R Myers, David R. Cox, M R James, D. R. Bentley, Panos Deloukas, Eric S. Lander, Thomas J. Hudson
Science
October 25, 1996
10.1126/science.274.5287.540
Cited by 758

Abstract

The human genome is thought to harbor 50,000 to 100,000 genes, of which about half have been sampled to date in the form of expressed sequence tags. An international consortium was organized to develop and map gene-based sequence tagged site markers on a set of two radiation hybrid panels and a yeast artificial chromosome library. More than 16,000 human genes have been mapped relative to a framework map that contains about 1000 polymorphic genetic markers. The gene map unifies the existing genetic and physical maps with the nucleotide and protein sequence databases in a fashion that should speed the discovery of genes underlying inherited human disease. The integrated resource is available through a site on the World Wide Web at http://www.ncbi.nlm.nih.gov/SCIENCE96/ .

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