The human placenta shapes the phenotype of decidual macrophages
Sigrid Vondra(Medical University of Vienna), Anna-Lena Höbler(Medical University of Vienna), Andreas Ian Lackner(Medical University of Vienna), Johanna Raffetseder(Linköping University), Zala Nikita Mihalič(Medical University of Graz), Andrea Vogel(Christian Doppler Laboratory for Thermoelectricity), Leila Saleh(Medical University of Vienna), Victoria Kunihs(Medical University of Vienna), Peter Haslinger(Medical University of Vienna), Markus Wahrmann(Medical University of Vienna), H Husslein(Medical University of Vienna), Raimund Oberle(Medical University of Vienna), Julia Kargl(Medical University of Graz), Sandra Haider(Medical University of Vienna), Paulina A. Latos(Medical University of Vienna), Gernot Schabbauer(Christian Doppler Laboratory for Thermoelectricity), Martin Knöfler(Medical University of Vienna), Jan Ernerudh(Linköping University), Jürgen Pollheimer(Medical University of Vienna)
Cited by 41Open Access
Abstract
and efficient inducers of Tregs, proliferate in situ, and secrete high levels of CXCL1, CXCL5, M-CSF, and IL-10. In contrast, decPAMs exert a dendritic cell-like, motile phenotype characterized by induced expression of HLA class II molecules, enhanced phagocytosis, and the ability to activate T cells. Strikingly, EVT-conditioned media convert decPAMs into a decBAM phenotype. These findings assign distinct macrophage phenotypes to decidual areas depending on placentation and further highlight a critical role for EVTs in the induction of decB-associated macrophage polarization.
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