NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

Writing Group; Patty J. Lee; Christopher C. Benz; Philip D. Blood; Katy Börner; Judith Campisi; Feng Chen; Heike E. Daldrup‐Link; Phil De Jager; Li Ding; Francesca E. Duncan; Oliver Eickelberg; Rong Fan; Toren Finkel; David Furman; Vesna D. Garovic; Nils Gehlenborg; Carolyn Glass; Indra Heckenbach; Ziv-Bar Joseph; Pragati Katiyar; Sojin Kim; Mélanie Königshoff; George A. Kuchel; Haesung Lee; Jun Hee Lee; Jian Ma; Qin Ma; Simon Melov; Kay Metis; Ana L. Mora; Nicolas Musi; Nicola Neretti; João F. Passos; Irfan Rahman; Juan Carlos Rivera‐Mulia; Paul Robson; Mauricio Rojas; Ananda L. Roy; Morten Scheibye‐Knudsen; Birgit Schilling; Pixu Shi; Jonathan C. Silverstein; Vidyani Suryadevara; Jichun Xie; Jinhua Wang; A. Ian Wong; Laura J. Niedernhofer; Siyuan Wang; Hannah Anvari; Julia L. Balough; Christopher C. Benz; Joanna Bons; Boris Brenerman; William J. Evans; Akos A. Gerencser; Heather Gregory; Malene Hansen; Jamie N. Justice; Pankaj Kapahi; Natália Faraj Murad; Amy O’Broin; Mary Ellen Pavone; Mark Powell; Gary K. Scott; Elisheva D. Shanes; Mahalakshmi Shankaran; Eric Verdin; Daniel A. Winer; Fei Wu; Andrew I. Adams; Philip D. Blood; Andreas Bueckle; Ivan Cao-Berg; Hao Chen; Michael J. Davis; Shane Filus; Yuhan Hao; Austin Hartman; Euxhen Hasanaj; Jesse Helfer; Bruce Herr; Ziv Bar‐Joseph; Gesmira Molla; Gloria Mou; Juan Puerto; Ellen M. Quardokus; Alexander J. Ropelewski; Matt Ruffalo; Rahul Satija; Melissa Schwenk; Robin Scibek; William Shirey; Max Sibilla; Joel Welling; Yuan Zhou; Columbia TMC; Richard Bonneau; Angela M. Christiano; Benjamin Izar; Vilas Menon; David M. Owens; Hemali Phatnani; Colin Smith; Yousin Suh; Andrew F. Teich; Valerie Bekker; Cliburn Chan; Elias Coutavas; Matthew G. Hartwig; Zhicheng Ji; Andrew B. Nixon; Zhixun Dou; Jayaraj Rajagopal; Nikolai Slavov; David R. Holmes; Diana Jurk; James L. Kirkland; Anthony B. Lagnado; Tamar Tchkonia; Kristin Abraham; Amanda M. DiBattista; Yih-Woei C. Fridell; T. Kevin Howcroft; Chamelli Jhappan; Viviana Perez Montes; Mercy PrabhuDas; Haluk Resat; Veronica Taylor; Stanford TDA; Manoj Kumar; Vidyani Suryadevara; Francisco Cigarroa; Rachel Cohn; Tiffany Cortes; Elise T. Courtois; Jeffrey H. Chuang; Monica Davé; Sergii Domanskyi; Elizabeth Ann L. Enninga; Giray Naim Eryilmaz; Sara Espinoza; Jon Gelfond; James L. Kirkland; George A. Kuchel; Chia‐Ling Kuo; Julia S. Lehman; Cristina Aguayo‐Mazzucato; Alexander Meves; Meenakshi Rani; Shane Sanders; Asa Thibodeau; Stefan G. Tullius; Duygu Ucar; Brian S. White; Qian Wu; Ming Xu; Seiji Yamaguchi; Naziheh Assarzadegan; Chun‐Seok Cho; Irene Hwang; Yongha Hwang; Jingyue Xi; Oyedele Adeyi; Constantin Aliferis; Alessandro Bartolomucci; Xiao Dong; Mickayla J. DuFresne-To; Sayeed Ikramuddin; Steve Johnson; Andrew C. Nelson; Laura J. Niedernhofer; Xavier S. Revelo; Claudia Trevilla‐García; John M. Sedivy; Elizabeth L. Thompson; Paul D. Robbins; Jinhua Wang; Katherine M. Aird; Jonathan K. Alder; Delphine Beaulieu; Marta Bueno; Jazmín Calyeca; Julián A. Chamucero-Millaris; Stephen Y. Chan; Dongjun Chung; Anthony Corbett; Vera Gorbunova; Kymberly M. Gowdy; Aditi U. Gurkar; Jeffrey C. Horowitz; Qianjiang Hu; Gagandeep Kaur; Timur O. Khaliullin; Robert Lafyatis; Serafina Lanna; Dongmei Li; Anjun Ma; Alison Morris; Thivanka Muthumalage; Victor Peters; Gloria Pryhuber; Brenda F. Reader; Lorena Rosas; John Sembrat; Sadiya Bi Shaikh; Hangchuan Shi; Sean D. Stacey; Claudette M. St. Croix; Cankun Wang; Qixin Wang; Andrew Watts; Liangcai Gu; Yiing Lin; Peter S. Rabinovitch; Mariya T. Sweetwyne; Maxim N. Artyomov; Samuel Ballentine; Milan G. Chheda; Sherri R. Davies; John F. DiPersio; Ryan C. Fields; James A. J. Fitzpatrick; Robert S. Fulton; Shin‐ichiro Imai; Sanjay Jain; Tao Ju; Vladimir Kushnir; Daniel C. Link; Michael Ben Major; Stephen T. Oh; Daniel Rapp; Michael P. Rettig; Shelia Stewart; Deborah J. Veis; Kiran Vij; Michael C. Wendl; Matthew A. Wyczalkowski; Yale TMC; Joseph Craft; Archibald Enninful; Negin Farzad; Peter Gershkovich; Stephanie Halene; Yuval Kluger; Jennifer VanOudenhove; Mina L. Xu; Junchen Yang; Ming‐Yu Yang

doi:10.1038/s43587-022-00326-5

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health

Writing Group(Duke University), Patty J. Lee(Buck Institute for Research on Aging), Christopher C. Benz(Buck Institute for Research on Aging), Philip D. Blood(Pittsburgh Supercomputing Center), Katy Börner(Buck Institute for Research on Aging), Judith Campisi(Buck Institute for Research on Aging), Feng Chen(Washington University in St. Louis), Heike E. Daldrup‐Link(Columbia University), Phil De Jager(Washington University in St. Louis), Li Ding(Northwestern University), Francesca E. Duncan(Northwestern University), Oliver Eickelberg(University of Pittsburgh), Rong Fan(University of Pittsburgh), Toren Finkel(Buck Institute for Research on Aging), David Furman(Buck Institute for Research on Aging), Vesna D. Garovic(Harvard University), Nils Gehlenborg(Harvard University), Carolyn Glass(Buck Institute for Research on Aging), Indra Heckenbach(Buck Institute for Research on Aging), Ziv-Bar Joseph(National Institute on Aging), Pragati Katiyar(Duke University), Sojin Kim(University of Pittsburgh), Mélanie Königshoff(University of Pittsburgh), George A. Kuchel(Duke University), Haesung Lee(Duke University), Jun Hee Lee(University of Michigan), Jian Ma(The Ohio State University), Qin Ma(Buck Institute for Research on Aging), Simon Melov(Buck Institute for Research on Aging), Kay Metis(University of Pittsburgh), Ana L. Mora(The University of Texas at San Antonio Health Science Center), Nicolas Musi(The University of Texas at San Antonio Health Science Center), Nicola Neretti(Brown University), João F. Passos(University of Rochester Medical Center), Irfan Rahman(University of Minnesota), Juan Carlos Rivera‐Mulia(University of Minnesota), Paul Robson(Lung Institute), Mauricio Rojas(National Institutes of Health), Ananda L. Roy(University of Copenhagen), Morten Scheibye‐Knudsen(University of Copenhagen), Birgit Schilling(Buck Institute for Research on Aging), Pixu Shi(University of Pittsburgh), Jonathan C. Silverstein(University of Pittsburgh), Vidyani Suryadevara(Duke University), Jichun Xie(University of Minnesota), Jinhua Wang(University of Minnesota), A. Ian Wong(University of Minnesota), Laura J. Niedernhofer(University of Minnesota), Siyuan Wang(Northwestern University), Hannah Anvari(Northwestern University), Julia L. Balough(Buck Institute for Research on Aging), Christopher C. Benz(Buck Institute for Research on Aging), Joanna Bons(Buck Institute for Research on Aging), Boris Brenerman(Buck Institute for Research on Aging), William J. Evans(Buck Institute for Research on Aging), Akos A. Gerencser(Buck Institute for Research on Aging), Heather Gregory(Buck Institute for Research on Aging), Malene Hansen(Buck Institute for Research on Aging), Jamie N. Justice(Buck Institute for Research on Aging), Pankaj Kapahi(Buck Institute for Research on Aging), Natália Faraj Murad(Buck Institute for Research on Aging), Amy O’Broin(Northwestern University), Mary Ellen Pavone(Northwestern University), Mark Powell(Buck Institute for Research on Aging), Gary K. Scott(Northwestern University), Elisheva D. Shanes(Northwestern University), Mahalakshmi Shankaran(Buck Institute for Research on Aging), Eric Verdin(Buck Institute for Research on Aging), Daniel A. Winer(Buck Institute for Research on Aging), Fei Wu(Buck Institute for Research on Aging), Andrew I. Adams(Pittsburgh Supercomputing Center), Philip D. Blood(Pittsburgh Supercomputing Center), Andreas Bueckle(Pittsburgh Supercomputing Center), Ivan Cao-Berg(Pittsburgh Supercomputing Center), Hao Chen(University of Pittsburgh), Michael J. Davis(University of Pittsburgh), Shane Filus(Pittsburgh Supercomputing Center), Yuhan Hao(New York Genome Center), Austin Hartman(New York Genome Center), Euxhen Hasanaj(University of Pittsburgh), Jesse Helfer(University of Pittsburgh), Bruce Herr(Indiana University Bloomington), Ziv Bar‐Joseph(New York Genome Center), Gesmira Molla(Pittsburgh Supercomputing Center), Gloria Mou(Pittsburgh Supercomputing Center), Juan Puerto(Pittsburgh Supercomputing Center), Ellen M. Quardokus(Pittsburgh Supercomputing Center), Alexander J. Ropelewski(Pittsburgh Supercomputing Center), Matt Ruffalo(New York Genome Center), Rahul Satija(University of Pittsburgh), Melissa Schwenk(University of Pittsburgh), Robin Scibek(University of Pittsburgh), William Shirey(University of Pittsburgh), Max Sibilla(University of Pittsburgh), Joel Welling(University of Pittsburgh), Yuan Zhou(University of Pittsburgh), Columbia TMC(Columbia University), Richard Bonneau(Columbia University Irving Medical Center), Angela M. Christiano(Columbia University), Benjamin Izar(Columbia University Irving Medical Center), Vilas Menon(Columbia University), David M. Owens(Columbia University), Hemali Phatnani(Columbia University), Colin Smith(Columbia University), Yousin Suh(Duke University), Andrew F. Teich(Duke University), Valerie Bekker(Duke University), Cliburn Chan(Duke University), Elias Coutavas(Duke University), Matthew G. Hartwig(Duke University), Zhicheng Ji(Duke University), Andrew B. Nixon(Duke University), Zhixun Dou(Northeastern University), Jayaraj Rajagopal(Massachusetts General Hospital), Nikolai Slavov(Northeastern University), David R. Holmes(Mayo Clinic in Arizona), Diana Jurk(Mayo Clinic in Arizona), James L. Kirkland(Mayo Clinic in Arizona), Anthony B. Lagnado(National Institute of Diabetes and Digestive and Kidney Diseases), Tamar Tchkonia(Mayo Clinic in Arizona), Kristin Abraham(National Institute of Diabetes and Digestive and Kidney Diseases), Amanda M. DiBattista(National Institute on Aging), Yih-Woei C. Fridell(National Institute on Aging), T. Kevin Howcroft(National Institute on Aging), Chamelli Jhappan(National Institute of Allergy and Infectious Diseases), Viviana Perez Montes(National Institutes of Health), Mercy PrabhuDas(National Institutes of Health), Haluk Resat(National Institutes of Health), Veronica Taylor(National Institutes of Health), Stanford TDA(The University of Texas at San Antonio Health Science Center), Manoj Kumar(UConn Health), Vidyani Suryadevara(The University of Texas at San Antonio Health Science Center), Francisco Cigarroa(The University of Texas at San Antonio Health Science Center), Rachel Cohn(Jackson Laboratory), Tiffany Cortes(The University of Texas at San Antonio Health Science Center), Elise T. Courtois(Jackson Laboratory), Jeffrey H. Chuang(Jackson Laboratory), Monica Davé(Jackson Laboratory), Sergii Domanskyi(The University of Texas at San Antonio Health Science Center), Elizabeth Ann L. Enninga(Jackson Laboratory), Giray Naim Eryilmaz(Jackson Laboratory), Sara Espinoza(The University of Texas at San Antonio Health Science Center), Jon Gelfond(Jackson Laboratory), James L. Kirkland(Mayo Clinic in Arizona), George A. Kuchel(Joslin Diabetes Center), Chia‐Ling Kuo(Mayo Clinic in Arizona), Julia S. Lehman(The University of Texas at San Antonio Health Science Center), Cristina Aguayo‐Mazzucato(Joslin Diabetes Center), Alexander Meves(Jackson Laboratory), Meenakshi Rani(Brigham and Women's Hospital), Shane Sanders(Jackson Laboratory), Asa Thibodeau(Jackson Laboratory), Stefan G. Tullius(Brigham and Women's Hospital), Duygu Ucar(Jackson Laboratory), Brian S. White(The University of Texas at San Antonio Health Science Center), Qian Wu(University of Michigan), Ming Xu(University of Michigan), Seiji Yamaguchi(The University of Texas at San Antonio Health Science Center), Naziheh Assarzadegan(University of Michigan), Chun‐Seok Cho(University of Michigan), Irene Hwang(University of Minnesota), Yongha Hwang(University of Minnesota), Jingyue Xi(University of Minnesota), Oyedele Adeyi(University of Minnesota), Constantin Aliferis(University of Minnesota), Alessandro Bartolomucci(University of Minnesota), Xiao Dong(University of Minnesota), Mickayla J. DuFresne-To(University of Minnesota), Sayeed Ikramuddin(University of Minnesota), Steve Johnson(University of Minnesota), Andrew C. Nelson(University of Minnesota), Laura J. Niedernhofer(University of Minnesota), Xavier S. Revelo(University of Minnesota), Claudia Trevilla‐García(University of Minnesota), John M. Sedivy(Brown University), Elizabeth L. Thompson(University of Minnesota), Paul D. Robbins(University of Minnesota), Jinhua Wang(University of Minnesota), Katherine M. Aird(Lung Institute), Jonathan K. Alder(University of Pittsburgh), Delphine Beaulieu(University of Pittsburgh), Marta Bueno(University of Pittsburgh), Jazmín Calyeca(University of Rochester Medical Center), Julián A. Chamucero-Millaris(Lung Institute), Stephen Y. Chan(University of Pittsburgh), Dongjun Chung(University of Pittsburgh), Anthony Corbett(University of Rochester Medical Center), Vera Gorbunova(University of Pittsburgh), Kymberly M. Gowdy(University of Rochester Medical Center), Aditi U. Gurkar(University of Pittsburgh), Jeffrey C. Horowitz(University of Pittsburgh), Qianjiang Hu(University of Pittsburgh), Gagandeep Kaur(University of Rochester Medical Center), Timur O. Khaliullin(Lung Institute), Robert Lafyatis(University of Pittsburgh), Serafina Lanna(University of Pittsburgh), Dongmei Li(University of Rochester Medical Center), Anjun Ma(University of Rochester Medical Center), Alison Morris(University of Pittsburgh), Thivanka Muthumalage(University of Rochester Medical Center), Victor Peters(University of Pittsburgh), Gloria Pryhuber(University of Rochester Medical Center), Brenda F. Reader(The Ohio State University Wexner Medical Center), Lorena Rosas(The Ohio State University Wexner Medical Center), John Sembrat(University of Pittsburgh), Sadiya Bi Shaikh(University of Rochester Medical Center), Hangchuan Shi(University of Rochester Medical Center), Sean D. Stacey(The Ohio State University Wexner Medical Center), Claudette M. St. Croix(University of Pittsburgh), Cankun Wang(Washington University in St. Louis), Qixin Wang(University of Washington), Andrew Watts(University of Washington), Liangcai Gu(University of Washington), Yiing Lin(Washington University in St. Louis), Peter S. Rabinovitch(University of Washington), Mariya T. Sweetwyne(University of Washington), Maxim N. Artyomov(Washington University in St. Louis), Samuel Ballentine(Washington University in St. Louis), Milan G. Chheda(Washington University in St. Louis), Sherri R. Davies(Washington University in St. Louis), John F. DiPersio(Washington University in St. Louis), Ryan C. Fields(Washington University in St. Louis), James A. J. Fitzpatrick(Washington University in St. Louis), Robert S. Fulton(Washington University in St. Louis), Shin‐ichiro Imai(Washington University in St. Louis), Sanjay Jain(Washington University in St. Louis), Tao Ju(Washington University in St. Louis), Vladimir Kushnir(Washington University in St. Louis), Daniel C. Link(Washington University in St. Louis), Michael Ben Major(Washington University in St. Louis), Stephen T. Oh(Washington University in St. Louis), Daniel Rapp(Washington University in St. Louis), Michael P. Rettig(Washington University in St. Louis), Shelia Stewart(Washington University in St. Louis), Deborah J. Veis(Washington University in St. Louis), Kiran Vij(Washington University in St. Louis), Michael C. Wendl(Washington University in St. Louis), Matthew A. Wyczalkowski(Washington University in St. Louis), Yale TMC(Yale University), Joseph Craft(Yale University), Archibald Enninful(Yale University), Negin Farzad(Yale University), Peter Gershkovich(Yale University), Stephanie Halene(Yale University), Yuval Kluger(Yale University), Jennifer VanOudenhove(Yale University), Mina L. Xu(Yale University), Junchen Yang(Yale University), Ming‐Yu Yang(Yale University)

Nature Aging

December 20, 2022

10.1038/s43587-022-00326-5

Cited by 122Open Access

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