IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
Olga Blomberg(Leiden University), Lorenzo Spagnuolo(The Netherlands Cancer Institute), Hannah Garner(The Netherlands Cancer Institute), Leonie Voorwerk(The Netherlands Cancer Institute), Olga I. Isaeva(The Netherlands Cancer Institute), Ewald van Dyk(The Netherlands Cancer Institute), Noor A. M. Bakker(The Netherlands Cancer Institute), Myriam Chalabi(The Netherlands Cancer Institute), Chris Klaver(The Netherlands Cancer Institute), Maxime Duijst(The Netherlands Cancer Institute), Kelly Kersten(The Netherlands Cancer Institute), Marieke Brüggemann(The Netherlands Cancer Institute), Dorien Pastoors(The Netherlands Cancer Institute), Cheei‐Sing Hau(The Netherlands Cancer Institute), Kim Vrijland(The Netherlands Cancer Institute), Elisabeth A.M. Raeven(The Netherlands Cancer Institute), Daphne Kaldenbach(The Netherlands Cancer Institute), Kevin Kos(Leiden University), Inna S. Afonina(Ghent University), Paulien Kaptein(The Netherlands Cancer Institute), Louisa R. Hoes(The Netherlands Cancer Institute), Willemijn S.M.E. Theelen(The Netherlands Cancer Institute), Paul Baas(The Netherlands Cancer Institute), Emile E. Voest(The Netherlands Cancer Institute), Rudi Beyaert(Ghent University), Daniela S. Thommen(The Netherlands Cancer Institute), Lodewyk F.A. Wessels(The Netherlands Cancer Institute), Karin E. de Visser(Leiden University), Marleen Kok(The Netherlands Cancer Institute)
Cited by 205Open Access
Abstract
T cell activation to enhance ICB response. This work demonstrates the critical role of eosinophils in ICB response and provides proof-of-principle for eosinophil engagement to enhance ICB efficacy.
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