Single-cell RNA sequencing reveals distinct T cell populations in immune-related adverse events of checkpoint inhibitors
Shoiab Bukhari(Columbia University Irving Medical Center), Brian S. Henick(Columbia University Irving Medical Center), Robert Winchester(Columbia University Irving Medical Center), Shalom Lerrer(Columbia University Irving Medical Center), Kieran Adam(Columbia University Irving Medical Center), Yevgeniya Gartshteyn(Columbia University Irving Medical Center), Rohan Maniar(Columbia University Irving Medical Center), Ziyan Lin, Alireza Khodadadi‐Jamayran, Aristotelis Tsirigos, Mary Salvatore(Columbia University Irving Medical Center), Galina Lagos(Columbia University Irving Medical Center), Steven L. Reiner(Columbia University Irving Medical Center), Matthew C. Dallos(Columbia University Irving Medical Center), Matthen Mathew(Columbia University Irving Medical Center), Naiyer A. Rizvi(Columbia University Irving Medical Center), Adam Mor(Columbia University Irving Medical Center)
Cited by 81Open Access
Abstract
cells when compared with patients who do not develop irAEs. These data support the hypothesis that different populations of T cells are associated with different irAEs and that characterization of these cells' pre-treatment has the potential to serve as a toxicity-specific predictive biomarker.
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