Malaria : parasite biology, pathogenesis, and protection

Abstract

A Brief History of Malaria and Discovery of the Parasite's Life Cycle The Current Global Malaria Situation Gametocytes and Sexual Development Sporogonic Development in the Mosquito Engineering Resistance to Malaria Parasite Development in Mosquitoes Invasion of Vertebrate Cells: Hepatocytes Invasion of Vertebrate Cells: Erythrocytes Ultrastructure of Asexual Stages Carbohydrate Metabolism of Asexual Stages Hemoglobin Processing and the Metabolism of Amino Acids, Heme and Iron Malarial Lipids Purine and Pyrimidine Metabolism of Asexual Stages Malaria Parasite DNA The Plasmodium rRNA Genes Membrane Transport in the Malaria-Infected Erythrocyte The Genetic Structure of Malaria Parasite Populations Genome Discovery and Malaria Research: Current Status and Promise Extrachromosomal DNA: the Mitochondrion Extrachromosomal DNA: Plastid DNA Evolutionary Relationships of Human Malaria Parasites Introduction to the Modes of Action of and Mechanisms of Resistance to Anitmalarials The Molecular Basis of Resistance to the Sulfones, Sulfamides, and Dihydrofolate Reductase Inhibitors Chloroquine: Modes of Actions and Resistance and the Activity of Chloroquine Analogs From Quinine to Qinghaosu: Historical Perspectives Mitochondrial Physiology as a Target for Atovaquone and Other Antimalarials Malaria Pathophysiology Rosetting of Malaria-Infected Erythrocytes Animal Models: Rodents Animal Models: Primates Host Genetic Factors in Resistance to Malaria Acquired Immunity to Sexual Stages Acquired Immunity to Asexual Blood Stages Acquired Immunity to Sporozoites Immunity to Liver Stages Using DNA-Based Vaccine Technology and the Malaria Genome Project to Overcome Obstacles to Malaria Vaccine Development.