BRCA2 gene mutation in cancer
Chunbao Xie(University of Electronic Science and Technology of China), Jiangrong Luo(Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital), Yangjun He(Southwest Medical University), Lingxi Jiang(University of Electronic Science and Technology of China), Ling Zhong(University of Electronic Science and Technology of China), Yi Shi(University of Electronic Science and Technology of China)
Cited by 34Open Access
Abstract
Breast cancer susceptibility gene 2 (BRCA2) is the main gene associated with hereditary breast cancers. However, a mutation in BRCA2 has also been found in other tumors, such as ovarian, pancreatic, thyroid, gastric, laryngeal, and prostate cancers. In this review, we discuss the biological functions of BRCA2 and the role of BRCA2 mutations in tumor progression and therapy.
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