Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury

Wuxuan Wang(University of Science and Technology of China), Zheng Zhang(University of Science and Technology of China), Yi Liu(University of Science and Technology of China), Lingqi Kong(University of Science and Technology of China), Wenyu Li(University of Science and Technology of China), Wei Hu(University of Science and Technology of China), Yucai Wang(University of Science and Technology of China), Xinfeng Liu(University of Science and Technology of China)
Biomaterials Science
January 1, 2022
10.1039/d2bm01401g
Cited by 24

Abstract

. We further showed that the neutrophil-mediated delivery of antioxidases effectively reduced oxidative damage and apoptosis of neurons in brain tissue in a transient middle cerebral artery occlusion (tMCAO) mouse model. Moreover, the successful delivery of Se with the nanoparticles increased the expression of glutathione peroxidase 4 (GPX4) and effectively inhibited neuronal ferroptosis, achieving a satisfactory neuroprotective effect in I/R injury mice. Our study demonstrated that the rationally designed nanomedicines using the "neutrophil piggybacking" strategy can efficiently penetrate the BBB, greatly expanding the application of nanomedicines in the treatment of central nervous system (CNS) diseases.

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