Ensembl 2023

Fergal J. Martin(European Bioinformatics Institute), M Ridwan Amode(European Bioinformatics Institute), Alisha Aneja(European Bioinformatics Institute), Olanrewaju Austine-Orimoloye(European Bioinformatics Institute), Andrey G Azov(European Bioinformatics Institute), If Barnes(European Bioinformatics Institute), Arne Becker(European Bioinformatics Institute), Ruth Bennett(European Bioinformatics Institute), Andrew Berry(European Bioinformatics Institute), Jyothish Bhai(European Bioinformatics Institute), Simarpreet Kaur Bhurji(European Bioinformatics Institute), Alexandra Bignell(European Bioinformatics Institute), Sanjay Boddu(European Bioinformatics Institute), Paulo Lins(European Bioinformatics Institute), Lucy Brooks(European Bioinformatics Institute), Shashank Budhanuru Ramaraju(European Bioinformatics Institute), Mehrnaz Charkhchi(European Bioinformatics Institute), Alexander Cockburn(European Bioinformatics Institute), Luca Da Rin Fiorretto(European Bioinformatics Institute), Claire Davidson(European Bioinformatics Institute), Kamalkumar Dodiya(European Bioinformatics Institute), Sarah Donaldson(European Bioinformatics Institute), Bilal El Houdaigui(European Bioinformatics Institute), Tamara El Naboulsi(European Bioinformatics Institute), Reham Fatima(European Bioinformatics Institute), Carlos García Girón(European Bioinformatics Institute), Thiago A. L. Genez(European Bioinformatics Institute), Gurpreet S Ghattaoraya(European Bioinformatics Institute), José M. González(European Bioinformatics Institute), Cristina Guijarro-Clarke(European Bioinformatics Institute), Matthew P. Hardy(European Bioinformatics Institute), Zoe Hollis(European Bioinformatics Institute), Thibaut Hourlier(European Bioinformatics Institute), Toby Hunt(European Bioinformatics Institute), Mike Kay(European Bioinformatics Institute), Vinay Kaykala(European Bioinformatics Institute), Anh Tuấn Lê(European Bioinformatics Institute), Diana Lemos(European Bioinformatics Institute), Diego Marques‐Coelho(European Bioinformatics Institute), José Carlos Marugán(European Bioinformatics Institute), Gabriela Merino(European Bioinformatics Institute), Louisse Paola Mirabueno(European Bioinformatics Institute), Aleena Mushtaq(European Bioinformatics Institute), Syed Nakib Hossain(European Bioinformatics Institute), Denye Ogeh(European Bioinformatics Institute), Manoj Pandian Sakthivel(European Bioinformatics Institute), Anne Parker(European Bioinformatics Institute), Malcolm Perry(European Bioinformatics Institute), Ivana Piližota(European Bioinformatics Institute), Irina Prosovetskaia(European Bioinformatics Institute), José G Pérez-Silva(European Bioinformatics Institute), Ahamed Imran Abdul Salam(European Bioinformatics Institute), Nuno Saraiva-Agostinho(European Bioinformatics Institute), Helen Schuilenburg(European Bioinformatics Institute), Dan Sheppard(European Bioinformatics Institute), Swati Sinha(European Bioinformatics Institute), Botond Sipos(European Bioinformatics Institute), William Stark(European Bioinformatics Institute), Emily Steed(European Bioinformatics Institute), Ranjit Sukumaran(European Bioinformatics Institute), Dulika Sumathipala(European Bioinformatics Institute), Marie‐Marthe Suner(European Bioinformatics Institute), Likhitha Surapaneni(European Bioinformatics Institute), Kyösti Sutinen(European Bioinformatics Institute), Michał Szpak(European Bioinformatics Institute), Francesca Floriana Tricomi(European Bioinformatics Institute), David Urbina-Gómez(European Bioinformatics Institute), Andres Veidenberg(European Bioinformatics Institute), Thomas Walsh(European Bioinformatics Institute), Brandon Walts(European Bioinformatics Institute), Elizabeth Wass(European Bioinformatics Institute), Natalie L Willhoft(European Bioinformatics Institute), Jamie Allen(European Bioinformatics Institute), Jorge Álvarez-Jarreta(European Bioinformatics Institute), Marc Chakiachvili(European Bioinformatics Institute), Bethany Flint(European Bioinformatics Institute), Stefano Giorgetti(European Bioinformatics Institute), Leanne Haggerty(European Bioinformatics Institute), Garth R Ilsley(European Bioinformatics Institute), Jane Loveland(European Bioinformatics Institute), Benjamin Moore(European Bioinformatics Institute), Jonathan M. Mudge(European Bioinformatics Institute), John Tate(European Bioinformatics Institute), David Thybert(European Bioinformatics Institute), Stephen J. Trevanion(European Bioinformatics Institute), Andrea Winterbottom(European Bioinformatics Institute), Adam Frankish(European Bioinformatics Institute), Sarah Hunt(European Bioinformatics Institute), Magali Ruffier(European Bioinformatics Institute), Fiona Cunningham(European Bioinformatics Institute), Sarah Dyer(European Bioinformatics Institute), ROBERT FINN(European Bioinformatics Institute), Kevin Howe(European Bioinformatics Institute), Peter W. Harrison(European Bioinformatics Institute), Andrew Yates(European Bioinformatics Institute), Paul Flicek(European Bioinformatics Institute)
Nucleic Acids Research
November 1, 2022
10.1093/nar/gkac958
Cited by 1,079Open Access
Full Text

Abstract

Ensembl (https://www.ensembl.org) has produced high-quality genomic resources for vertebrates and model organisms for more than twenty years. During that time, our resources, services and tools have continually evolved in line with both the publicly available genome data and the downstream research and applications that utilise the Ensembl platform. In recent years we have witnessed a dramatic shift in the genomic landscape. There has been a large increase in the number of high-quality reference genomes through global biodiversity initiatives. In parallel, there have been major advances towards pangenome representations of higher species, where many alternative genome assemblies representing different breeds, cultivars, strains and haplotypes are now available. In order to support these efforts and accelerate downstream research, it is our goal at Ensembl to create high-quality annotations, tools and services for species across the tree of life. Here, we report our resources for popular reference genomes, the dramatic growth of our annotations (including haplotypes from the first human pangenome graphs), updates to the Ensembl Variant Effect Predictor (VEP), interactive protein structure predictions from AlphaFold DB, and the beta release of our new website.

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