Application of Metagenomic Next-Generation Sequencing (mNGS) Using Bronchoalveolar Lavage Fluid (BALF) in Diagnosing Pneumonia of Children

Aimei Yang(Guangdong Academy of Medical Sciences), Chen Chen(Guangzhou Medical University), Yan Hu(Guangdong Academy of Medical Sciences), Guilang Zheng(Guangdong Academy of Medical Sciences), Peiling Chen(Guangdong Academy of Medical Sciences), Zhiwei Xie(Guangzhou Medical University), Huifeng Fan(Guangzhou Medical University), Yueyu Sun(Guangdong Academy of Medical Sciences), Peiqiong Wu(Guangzhou Medical University), Wenhui Jiang(Guangzhou Medical University), Chun Wang(Guangdong Academy of Medical Sciences), Jingwen Zhang(Guangdong Academy of Medical Sciences), Dongwei Zhang(Guangzhou Medical University), Jing Wang(Guangdong Academy of Medical Sciences), Xiao-Yin Hu(Guangzhou Medical University), Han Xia, Genquan Yin(Guangzhou Medical University), Yuxiong Guo(Guangdong Academy of Medical Sciences)
Microbiology Spectrum
September 28, 2022
10.1128/spectrum.01488-22
Cited by 95Open Access
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Abstract

Our study indicates high efficiency of mNGS using BALF for the detection of causative pathogens that cause pneumonia in children. mNGS can be a potential diagnostic tool to supplement conventional methods for children's pneumonia.

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