International Consensus Statement on Obstructive Sleep Apnea

Jolie L. Chang(University of California, San Francisco), Andrew N. Goldberg(University of California, San Francisco), Jeremiah A. Alt(University of Utah), Mohammed Alzoubaidi(Northwestern University), Liza Ashbrook(University of California, San Francisco), Dennis Auckley(Case Western Reserve University), Indu Ayappa(Icahn School of Medicine at Mount Sinai), H. Bakhtiar(Norwalk Hospital), José E. Barrera(Unifor), Bethany L. Bartley(Harvard University), Martha E. Billings(University of Washington), Maurits Boon(Thomas Jefferson University), Pien F. N. Bosschieter(Academic Center for Dentistry Amsterdam), Itzhak Braverman(Hillel Yaffe Medical Center), Kara D. Brodie(University of California, San Francisco), Cristina Cabrera‐Muffly(University of Colorado Denver), Ray Caesar(American Association of Orthodontists), Michel Burihan Cahali(Universidade de São Paulo), Yi Cai(University of California, San Francisco), Michelle Cao(Palo Alto University), Robson Capasso(Palo Alto University), Sean M. Caples(Mayo Clinic), Lana M. Chahine(University of Pittsburgh), Corissa P. Chang(University of Pennsylvania), Katherine W. Chang(Washington University in St. Louis), Nilika Chaudhary(Brigham and Women's Hospital), Crystal Cheong(National University Hospital), Susmita Chowdhuri(Wayne State University), Peter A. Cistulli(The University of Sydney), David M. Claman(University of California, San Francisco), Jacob Collen(Uniformed Services University of the Health Sciences), Kevin Coughlin(University of Tennessee Health Science Center), Jennifer Creamer(Uniformed Services University of the Health Sciences), Eric M. Davis(University of Virginia), Kara Dupuy-McCauley(Mayo Clinic), Megan L. Durr(Kaiser Permanente), Mohan Dutt(University of Michigan), Mazen El Ali(University of Pittsburgh), Nabil Elkassabany(University of Virginia), Lawrence J. Epstein(Harvard University), Justin A. Fiala(Northwestern University), Neil Freedman(University of Chicago), Kirat Gill(Palo Alto University), M. Boyd Gillespie(University of Tennessee Health Science Center), Lea Golisch(Heidelberg University), Nalaka S. Gooneratne(University of Pennsylvania), Daniel J. Gottlieb(Harvard University), Katherine K. Green(University of Colorado Anschutz Medical Campus), Arushi Gulati(University of California, San Francisco), Indira Gurubhagavatula(University of Pennsylvania), Nathan Hayward(Monash Health), Paul Hoff(University of Michigan), Oliver M. G. Hoffmann(Heidelberg University), Steven Holfinger(The Ohio State University), Jennifer Hsia(University of Minnesota), Colin Huntley(Thomas Jefferson University), Kevin C. Huoh(University of California, Irvine), Phillip Huyett(Harvard University), Sanjana Inala(Icahn School of Medicine at Mount Sinai), Stacey L. Ishman(University of Cincinnati), Tarun K. Jella(Case Western Reserve University), Aesha M. Jobanputra(Rutgers, The State University of New Jersey), Andrew P. Johnson(University of Colorado Denver), Mithri R. Junna(Mayo Clinic), Jenna T. Kado(University of Toledo), Thomas M. Kaffenberger(University of Pittsburgh), Vishesh K. Kapur(University of Washington), Eric J. Kezirian(University of Southern California), Meena Khan(The Ohio State University), Douglas B. Kirsch(University of North Carolina at Charlotte), Alan Kominsky(Cleveland Clinic), Meir H. Kryger(Yale University), Andrew D. Krystal(University of California, San Francisco), Clete A. Kushida(Palo Alto University), Thomas J. Kuzniar(University of Chicago), Derek J. Lam(Oregon Health & Science University), Christopher J. Lettieri(Uniformed Services University of the Health Sciences), Diane C Lim(University of Miami), Hsin‐Ching Lin(Chang Gung University), Stanley Yung‐Chuan Liu(Palo Alto University), Stuart G. MacKay(University of Wollongong), Ulysses J. Magalang(The Ohio State University), Atul Malhotra(University of California San Diego), Meghna P. Mansukhani(Mayo Clinic), Joachim T. Maurer(Heidelberg University), Anna M. May(Case Western Reserve University), Ron B. Mitchell(Children's Medical Center), Babak Mokhlesi(Rush University Medical Center), Anna Mullins(University of Chicago), Eman Nada(Stony Brook University), Sreelatha Naik(Geisinger Health System), Brandon Nokes(University of California San Diego), Michael D. Olson(Mayo Clinic), Allan I Pack(University of Pennsylvania), Edward B. Pang(University of Glasgow), Kenny P. Pang(Paragon 28 (United States)), Susheel P. Patil(Case Western Reserve University), Eli Van de Perck(University of Antwerp), Jay F. Piccirillo(Washington University in St. Louis), Grace W. Pien(Johns Hopkins University), Amanda J. Piper(The University of Sydney), Andrea Plawecki(Henry Ford Health System), Mark Quigg(University of Virginia), Madeline J. L. Ravesloot(OLVG), Susan Redline(Brigham and Women's Hospital), Brian Rotenberg(Western University), Armand Ryden(VA Greater Los Angeles Healthcare System), Kathleen Sarmiento(University of California, San Francisco), Firas Sbeih(Cleveland Clinic), Amy E. Schell(University of Colorado Anschutz Medical Campus), Christopher N. Schmickl(University of California San Diego), Helena Schotland(Icahn School of Medicine at Mount Sinai), Richard J. Schwab(University of Pennsylvania), Jiyeon Seo(University of California, Los Angeles), Neomi Shah(Icahn School of Medicine at Mount Sinai), Anita V. Shelgikar(University of Michigan), Isaac Shochat(Hillel Yaffe Medical Center), Ryan J. Soose(University of Pittsburgh), Toby O. Steele(University of California, Davis), Erika M. Stephens(University of California, San Francisco), Carl Stepnowsky(University of California San Diego), Kingman P. Strohl(Case Western Reserve University), Kate Sutherland(The University of Sydney), Maria V. Suurna(Cornell University), Erica R. Thaler(University of Pennsylvania), Sritika Thapa(Yale University), Olivier M. Vanderveken(University of Antwerp), Nico de Vries(Academic Center for Dentistry Amsterdam), Edward M. Weaver(University of Washington), Ian Weir(Yale University), Lisa F. Wolfe(Northwestern University), B. Tucker Woodson(Medical College of Wisconsin), Christine Won(Yale University), Josie Xu(University of Toronto), Pratyusha Yalamanchi(University of Michigan), Kathleen Yaremchuk(Henry Ford Health System), Yerem Yeghiazarians(University of California, San Francisco), Jason L. Yu(Emory University), Michelle Zeidler(University of California, Los Angeles), Ilene M. Rosen(University of Pennsylvania)
International Forum of Allergy & Rhinology
September 7, 2022
10.1002/alr.23079
Cited by 312Open Access
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Abstract

BACKGROUND: Evaluation and interpretation of the literature on obstructive sleep apnea (OSA) allows for consolidation and determination of the key factors important for clinical management of the adult OSA patient. Toward this goal, an international collaborative of multidisciplinary experts in sleep apnea evaluation and treatment have produced the International Consensus statement on Obstructive Sleep Apnea (ICS:OSA). METHODS: Using previously defined methodology, focal topics in OSA were assigned as literature review (LR), evidence-based review (EBR), or evidence-based review with recommendations (EBR-R) formats. Each topic incorporated the available and relevant evidence which was summarized and graded on study quality. Each topic and section underwent iterative review and the ICS:OSA was created and reviewed by all authors for consensus. RESULTS: The ICS:OSA addresses OSA syndrome definitions, pathophysiology, epidemiology, risk factors for disease, screening methods, diagnostic testing types, multiple treatment modalities, and effects of OSA treatment on multiple OSA-associated comorbidities. Specific focus on outcomes with positive airway pressure (PAP) and surgical treatments were evaluated. CONCLUSION: This review of the literature consolidates the available knowledge and identifies the limitations of the current evidence on OSA. This effort aims to create a resource for OSA evidence-based practice and identify future research needs. Knowledge gaps and research opportunities include improving the metrics of OSA disease, determining the optimal OSA screening paradigms, developing strategies for PAP adherence and longitudinal care, enhancing selection of PAP alternatives and surgery, understanding health risk outcomes, and translating evidence into individualized approaches to therapy.

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