Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae
Zoe Swank(Brigham and Women's Hospital), Yasmeen Senussi(Brigham and Women's Hospital), Zachary Manickas-Hill(Ragon Institute of MGH, MIT and Harvard), Xu G. Yu(Brigham and Women's Hospital), Jonathan Z. Li(Brigham and Women's Hospital), Galit Alter(Ragon Institute of MGH, MIT and Harvard), David R. Walt(Brigham and Women's Hospital)
Cited by 529Open Access
Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.
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