WHO CNS5 2021 classification of gliomas: a practical review and road signs for diagnosing pathologists and proper patho-clinical and neuro-oncological cooperation
Aleksandra Sejda(University of Warmia and Mazury in Olsztyn), Wiesława Grajkowska(Children's Memorial Health Institute), Joanna Trubicka(Children's Memorial Health Institute), Ewa Szutowicz(Gdańsk Medical University), Tomasz K. Wojdacz(Pomeranian Medical University), Wojciech Kloc(Copernicus Memorial Hospital), Ewa Iżycka‐Świeszewska(Copernicus Memorial Hospital)
Cited by 46Open Access
Abstract
The 5th edition of World Health Organization (WHO) Central Nervous System (CNS) tumours classification has transformed the pathological diagnosis of gliomas from purely histological to the multilayered integrated one with molecular biomarkers necessary for proper classification, risk stratification, and prognostic-predictive clinical purposes. Because of deep and important changes in taxonomy and diagnostic approach to gliomas, this manuscript is a review of WHO CNS classification 5th edition with general testing guidance for pathologists and clinicians working in neuro-oncology.
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