A pH-independent electrochemical aptamer-based biosensor supports quantitative, real-time measurement <i>in vivo</i>

Shaoguang Li(China University of Geosciences), Andrés Ferrer‐Ruiz(Universidad Complutense de Madrid), Jun Dai(Tongji Hospital), Javier Ramos‐Soriano(Universidad Complutense de Madrid), Xuewei Du(China University of Geosciences), Man Zhu(China University of Geosciences), Wanxue Zhang(China University of Geosciences), Yuanyuan Wang(China University of Geosciences), M. Ángeles Herranz(Universidad Complutense de Madrid), Jing Le(China University of Geosciences), Zishuo Zhang(China University of Geosciences), Hui Li(China University of Geosciences), Fan Xia(China University of Geosciences), Nazario Martı́n(Universidad Complutense de Madrid)
Chemical Science
January 1, 2022
10.1039/d2sc02021a
Cited by 35Open Access
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Abstract

An electrochemical aptamer-based sensor, enabling in vivo measurements of drug concentrations directly in the bladder of living rats under pH-variable conditions, was developed employing a π-extended tetrathiafulvalene (exTTF) as redox reported.

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