The<i>Staphylococcus aureus</i>Network Adaptive Platform Trial Protocol: New Tools for an Old Foe
Steven Y. C. Tong(The University of Melbourne), Jocelyn Mora(The University of Melbourne), Asha C Bowen(The Kids Research Institute Australia), Matthew P. Cheng(McGill University Health Centre), Nick Daneman(Sunnybrook Health Science Centre), Anna L. Goodman(St Thomas' Hospital), George Heriot(The University of Melbourne), Todd C. Lee(McGill University), Roger Lewis(University of California, Los Angeles), David Chien Lye(Tan Tock Seng Hospital), Robert K. Mahar(The University of Melbourne), Julie Marsh(The Kids Research Institute Australia), Anna McGlothlin(Berry & Associates (United States)), Zoe McQuilten(Monash Health), Susan C. Morpeth(Middlemore Hospital), David L. Paterson(The University of Queensland), David J. Price(The University of Melbourne), Jason Roberts(The University of Queensland), James O. Robinson(Murdoch University), Sebastiaan J. van Hal(The University of Sydney), Genevieve Walls(Middlemore Hospital), Steve Webb(Australian and New Zealand Intensive Care Society), Lyn Whiteway(Rabin Medical Center), Dafna Yahav(Rabin Medical Center), Joshua S. Davis(Sunnybrook Health Science Centre), for the Staphylococcus aureus Network Adaptive Platform (SNAP) Study Group, Nick Anagnostou, Sophia Archuleta, Eugene Athan, Lauren Barina, Emma Best, Max Bloomfield, Jennifer Bostock(The Kids Research Institute Australia), Carly L. Botheras, Asha C Bowen(The Kids Research Institute Australia), Philip N Britton, Hannah J. Burden, Anita J Campbell(McGill University Health Centre), Hannah Carter, Matthew P. Cheng(McGill University Health Centre), Ka Lip Chew, Russel Lee Ming Chong, Geoffrey W. Coombs(Sunnybrook Health Science Centre), Peter Daley, Nick Daneman(Sunnybrook Health Science Centre), Jane C. Davies, Joshua S. Davis(Hunter Medical Research Institute), Yael Dishon, Ravindra Dotel, Adrian Dunlop, Felicity Flack, Katie L. Flanagan, Hong Foo, Nesrin Ghanem‐Zoubi(St Thomas' Hospital), Stefano Giulieri, Anna L. Goodman(Sunnybrook Health Science Centre), Jennifer Grant, Dan Gregson, Stephen Guy, Amanda Gwee, Erica Hardy(The University of Melbourne), Andrew Henderson, George Heriot(The University of Melbourne), Benjamin P. Howden, Fleur Hudson, Jennie Johnstone, Shirin Kalimuddin, Dana de Kretser(McGill University), Andrea Lay‐Hoon Kwa, Todd A. Lee(Harbor–UCLA Medical Center), Amy Legg, Roger Lewis(University of California, Los Angeles), Martin Llewelyn(Tan Tock Seng Hospital), Thomas Lumley, David Chien Lye(The University of Melbourne), Derek R. MacFadden, Robert K. Mahar(The University of Melbourne), Isabelle Malhamé(The Kids Research Institute Australia), Michael Marks, Julie Marsh(The Kids Research Institute Australia), Marianne Martinello, Gail Matthews(Berry & Associates (United States)), Colin McArthur(Middlemore Hospital), Anna McGlothlin(Berry & Associates (United States)), Genevieve McKew(Monash Health), Brendan McMullan, Zoe McQuilten(The University of Melbourne), Eliza Milliken(Middlemore Hospital), Jocelyn Mora(The University of Melbourne), Susan C. Morpeth(Middlemore Hospital), Srinivas Murthy(McGill University Health Centre), Clare Nourse(The University of Queensland), Matthew O’Sullivan, David L. Paterson(The University of Queensland), Mical Paul, Neta Petersiel, Lina Petrella(The University of Melbourne), Sarah Pett(The University of Queensland), David J. Price(The University of Melbourne), Jason Roberts(The University of Queensland), Owen Robinson, Benedict D. Rogers(McGill University Health Centre), Benjamin R. Saville, Matthew Scarborough, Marc H. Scheetz, Oded Scheuerman, Kevin Schwartz, Simon Smith, Tom Snelling, Marta Soares, Christine Sommerville, Andrew J. Stewardson, Neil Stone(The University of Queensland), Archana Sud(The University of Melbourne), Robert Tilley, Steven Y. C. Tong(The University of Melbourne), R. Brigg Turner(The University of Sydney), Jonathan Underwood, Sebastiaan J. van Hal(The University of Sydney), Lesley Voss(Australian and New Zealand Intensive Care Society), Genevieve Walls(Middlemore Hospital), Rachel Webb, Steve Webb(Australian and New Zealand Intensive Care Society), Lynda Whiteway, Heather L. Wilson(Rabin Medical Center), Terence Wuerz, Dafna Yahav(Rabin Medical Center)
Cited by 95Open Access
Abstract
Staphylococcus aureus bloodstream (SAB) infection is a common and severe infectious disease, with a 90-day mortality of 15%-30%. Despite this, <3000 people have been randomized into clinical trials of treatments for SAB infection. The limited evidence base partly results from clinical trials for SAB infections being difficult to complete at scale using traditional clinical trial methods. Here we provide the rationale and framework for an adaptive platform trial applied to SAB infections. We detail the design features of the Staphylococcus aureus Network Adaptive Platform (SNAP) trial that will enable multiple questions to be answered as efficiently as possible. The SNAP trial commenced enrolling patients across multiple countries in 2022 with an estimated target sample size of 7000 participants. This approach may serve as an exemplar to increase efficiency of clinical trials for other infectious disease syndromes.
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