A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer
Yin Wu(King's College London), Dhruva Biswas(The Francis Crick Institute), Ieva Usaite(Cancer Research UK), Mihaela Angelova(The Francis Crick Institute), Stefan Boeing(The Francis Crick Institute), Takahiro Karasaki(The Francis Crick Institute), Selvaraju Veeriah(Cancer Research UK), Justyna Czyzewska-Khan(Cancer Research UK), Cienne Morton(King's College London), Magdalene Joseph(King's College London), Sonya Hessey(Cancer Research UK), James L. Reading(Cancer Research UK), Andrew Georgiou(Cancer Research UK), Maise Al-Bakir(The Francis Crick Institute), Nicolai J. Birkbak(Aarhus University), Gillian Price(Aberdeen Royal Infirmary), Mohammed S. Khalil(Aberdeen Royal Infirmary), Keith M. Kerr(Aberdeen Royal Infirmary), Shirley Richardson(Aberdeen Royal Infirmary), Heather Cheyne(Aberdeen Royal Infirmary), Tracey Cruickshank(Aberdeen Royal Infirmary), Gareth A. Wilson, Rachel Rosenthal, Hugo J.W.L. Aerts(Harvard University), Madeleine Hewish(Ashford and St Peter's Hospitals NHS Foundation Trust), Girija Anand(Chase Farm Hospital), Sajid Khan(Chase Farm Hospital), Kelvin Lau(Barts Health NHS Trust), Michael Sheaff(Barts Health NHS Trust), Peter Schmid(Barts Health NHS Trust), Louise Lim(Barts Health NHS Trust), John Conibear(Barts Health NHS Trust), Roland F. Schwarz(Max Delbrück Center), Tom L. Kaufmann(Max Delbrück Center), Matthew R. Huska(Max Delbrück Center), Jacqui Shaw(University of Leicester), Joan Riley(University of Leicester), Lindsay Primrose(University of Leicester), Dean A. Fennell(University of Leicester), Allan Hackshaw(Cancer Research UK), Yenting Ngai(Cancer Research UK), Abigail Sharp(Cancer Research UK), Oliver Pressey(Cancer Research UK), Sean Smith(Cancer Research UK), Nicole Gower(Cancer Research UK), Harjot Kaur Dhanda(Cancer Research UK), Kitty S. Chan(Cancer Research UK), Sonal Chakraborty(Cancer Research UK), Kevin Litchfield(Cancer Research UK), Krupa Thakkar(Cancer Research UK), Jonathan Tugwood(University of Manchester), Alexandra Clipson(University of Manchester), Caroline Dive(University of Manchester), Dominic G. Rothwell(Cancer Research UK), Alastair Kerr(University of Manchester), Elaine Kilgour(Cancer Research UK), Fiona J. E. Morgan(Cardiff and Vale University Health Board), Malgorzata Kornaszewska(Cardiff and Vale University Health Board), Richard Attanoos(Cardiff and Vale University Health Board), Helen Davies(Cardiff and Vale University Health Board), Katie Baker(The Christie NHS Foundation Trust), Mathew Carter(The Christie NHS Foundation Trust), Colin R. Lindsay(The Christie NHS Foundation Trust), Fábio Gomes(The Christie NHS Foundation Trust), Fiona Blackhall(Cancer Research UK), Lynsey Priest(Cancer Research UK), Matthew Krebs(Cancer Research UK), Anshuman Chaturvedi(Cancer Research UK), Pedro Oliveira(Cancer Research UK), Zoltán Szállási(Danish Cancer Society), Gary Royle(London Cancer), Catarina Veiga(London Cancer), Marcin Skrzypski(Gdańsk Medical University), Roberto Salgado, Miklós Dióssy(Eötvös Loránd University), Alan Kirk(Golden Jubilee National Hospital), Mo Asif(Golden Jubilee National Hospital), John Butler(Golden Jubilee National Hospital), Rocco Bilancia(Golden Jubilee National Hospital), Nikos Kostoulas(Golden Jubilee National Hospital), Mathew Thomas(Golden Jubilee National Hospital), Mairead MacKenzie(The Patients Association), Maggie Wilcox(The Patients Association), Apostolos Nakas(University Hospitals of Leicester NHS Trust), Sridhar Rathinam(University Hospitals of Leicester NHS Trust), Rebecca Boyles(University Hospitals of Leicester NHS Trust), Mohamad Tufail(University Hospitals of Leicester NHS Trust), Amrita Bajaj(University Hospitals of Leicester NHS Trust), Keng Ang(University Hospitals of Leicester NHS Trust), Mohammed Fiyaz Chowdhry(University Hospitals of Leicester NHS Trust), Michael Shackcloth(University of Liverpool), Julius Asante-Siaw(University of Liverpool), Angela Leek(Cancer Research UK Manchester Centre), Nicola Totten(Cancer Research UK Manchester Centre), Jack Davies Hodgkinson(Cancer Research UK Manchester Centre), Peter Van Loo(The University of Texas MD Anderson Cancer Center), William Monteiro(National Institute for Health and Care Research), Hilary Marshal(National Institute for Health and Care Research), Kevin G. Blyth(NHS Greater Glasgow and Clyde), Craig Dick(NHS Greater Glasgow and Clyde), Charles Fekete(Maastricht University), Eric Lim(Royal Brompton & Harefield NHS Foundation Trust), Paulo De Sousa(Royal Brompton & Harefield NHS Foundation Trust), Simon Jordan(Royal Brompton & Harefield NHS Foundation Trust), Alexandra Rice(Royal Brompton & Harefield NHS Foundation Trust), Hilgardt Raubenheimer(Royal Brompton & Harefield NHS Foundation Trust), Harshil Bhayani(Royal Brompton & Harefield NHS Foundation Trust), Morag Hamilton(Royal Brompton & Harefield NHS Foundation Trust), Lyn Ambrose(Royal Brompton & Harefield NHS Foundation Trust), Anand Devaraj(Royal Brompton & Harefield NHS Foundation Trust), Hemangi Chavan(Royal Brompton & Harefield NHS Foundation Trust), Sofina Begum(Royal Brompton & Harefield NHS Foundation Trust), Silviu Buderi(Royal Brompton & Harefield NHS Foundation Trust), Daniel Kaniu(Royal Brompton & Harefield NHS Foundation Trust), Mpho Malima(Royal Brompton & Harefield NHS Foundation Trust), Sarah Booth(Royal Brompton & Harefield NHS Foundation Trust), Andrew G. Nicholson(Royal Brompton & Harefield NHS Foundation Trust), Nadia Fernandes(Royal Brompton & Harefield NHS Foundation Trust), Pratibha Shah(Royal Brompton & Harefield NHS Foundation Trust), Chiara Proli(Royal Brompton & Harefield NHS Foundation Trust), John R. Gosney(University of Liverpool), Sarah Danson(Sheffield Teaching Hospitals NHS Foundation Trust), Jonathan Bury(Sheffield Teaching Hospitals NHS Foundation Trust), John Edwards(Sheffield Teaching Hospitals NHS Foundation Trust), Jennifer Hill(Sheffield Teaching Hospitals NHS Foundation Trust), Sue Matthews(Sheffield Teaching Hospitals NHS Foundation Trust), Yota Kitsanta(Sheffield Teaching Hospitals NHS Foundation Trust), Jagan Rao(Sheffield Teaching Hospitals NHS Foundation Trust), Sara Tenconi(Sheffield Teaching Hospitals NHS Foundation Trust), Laura Socci(Sheffield Teaching Hospitals NHS Foundation Trust), Kim Suvarna(Sheffield Teaching Hospitals NHS Foundation Trust), Faith Kibutu(Sheffield Teaching Hospitals NHS Foundation Trust), Patricia Fisher(Sheffield Teaching Hospitals NHS Foundation Trust), Robin Young(Sheffield Teaching Hospitals NHS Foundation Trust), Joann Barker(Sheffield Teaching Hospitals NHS Foundation Trust), Fiona Taylor(Sheffield Teaching Hospitals NHS Foundation Trust), Kirsty Lloyd(Sheffield Teaching Hospitals NHS Foundation Trust), J.F. Lester(Swansea Bay University Health Board), Mickael Escudero(The Francis Crick Institute), Aengus Stewart(The Francis Crick Institute), Andrew Rowan(The Francis Crick Institute), Jacki Goldman(The Francis Crick Institute), Richard Stone(The Francis Crick Institute), Tamara Denner(The Francis Crick Institute), Emma Nye(The Francis Crick Institute), Maria Greco(The Francis Crick Institute), Jérôme Nicod(The Francis Crick Institute), Clare Puttick(The Francis Crick Institute), Katey S.S. Enfield(The Francis Crick Institute), Emma Colliver(The Francis Crick Institute), Alastair Magness(The Francis Crick Institute), Chris Bailey(The Francis Crick Institute), Krijn K. Dijkstra(The Francis Crick Institute), Vittorio Barbè(The Francis Crick Institute), Roberto Vendramin(The Francis Crick Institute), Judit Kisistók(The Francis Crick Institute), Mateo Sokač(The Francis Crick Institute), Jonas Demeulemeester(The Francis Crick Institute), Elizabeth Larose Cadieux(The Francis Crick Institute), Carla Castignani(The Francis Crick Institute), Hongchang Fu(The Francis Crick Institute), Kristiana Grigoriadis(The Francis Crick Institute), Claudia Lee(The Francis Crick Institute), Foteini Athanasopoulou(The Francis Crick Institute), Crispin T. Hiley(The Francis Crick Institute), Lily Robinson(Princess Alexandra Hospital NHS Trust), Tracey Horey(Princess Alexandra Hospital NHS Trust), Peter Russell(Princess Alexandra Hospital NHS Trust), Dionysis Papadatos-Pastos(Princess Alexandra Hospital NHS Trust), Sara Lock(Whittington Hospital), Kayleigh Gilbert(Whittington Hospital), Kayalvizhi Selvaraju(London Cancer), Paul Ashford(London Cancer), Oriol Pich(London Cancer), Thomas B.K. Watkins(London Cancer), Sophia Ward(London Cancer), Emilia L. Lim(London Cancer), Alexander M. Frankell(London Cancer), Christopher Abbosh(London Cancer), Robert E. Hynds(London Cancer), Mariana Werner Sunderland(London Cancer), Karl S. Peggs(London Cancer), Teresa Marafioti(London Cancer), John A. Hartley(London Cancer), Helen L. Lowe(London Cancer), Leah Ensell(London Cancer), Victoria J. Spanswick(London Cancer), Angeliki Karamani(London Cancer), David A. Moore(London Cancer), Stephan Beck(London Cancer), Olga Chervova(London Cancer), Miljana Tanić(London Cancer), Ariana Huebner(London Cancer), Michelle Dietzen(London Cancer), James R. Black(London Cancer), Carlos Martinez Ruiz(London Cancer), Robert B. Bentham(London Cancer), Cristina Naceur‐Lombardelli(London Cancer), Hao-Ran Zhai(London Cancer), Nnennaya Kanu(London Cancer), Francisco Gimeno-Valiente(London Cancer), Supreet Kaur Bola(London Cancer), Ignacio Matos(London Cancer), Mansi Shah(Royal London Hospital), Felipe Galvez Cancino(London Cancer), Despoina Karagianni(London Cancer), Maryam Razaq(London Cancer), Mita Akther(London Cancer), Diana Johnson(London Cancer), Joanne Laycock(London Cancer), Elena Hoxha(London Cancer), Benny Chain(London Cancer), David R. Pearce(London Cancer), Kezhong Chen(London Cancer), Javier Herrero(London Cancer), Fleur Monk(London Cancer), Simone Zaccaria(London Cancer), Neil Magno(London Cancer), Paulina Prymas(London Cancer), Antonia Toncheva(London Cancer), Monica Sivakumar(London Cancer), Olivia Lucas(London Cancer), Mark S. Hill(London Cancer), Othman Al‐Sawaf(London Cancer), Seng Kuong Anakin Ung(Royal London Hospital), Sam Gamble(Royal London Hospital), Sophia Wong(Royal London Hospital), David Lawrence(Royal London Hospital), Martin Hayward(Royal London Hospital), Nikolaos Panagiotopoulos(Royal London Hospital), Robert George(Royal London Hospital), Davide Patrini(Royal London Hospital), Mary Falzon(Royal London Hospital), Elaine Borg(Royal London Hospital), Reena Khiroya(Royal London Hospital), Asia Ahmed(Royal London Hospital), Magali N. Taylor(Royal London Hospital), Junaid Choudhary(Royal London Hospital), Sam M. Janes(Royal London Hospital), Martin Förster(Royal London Hospital), Tanya Ahmad(Royal London Hospital), Siow Ming Lee(Royal London Hospital), Neal Navani(Royal London Hospital), Marco Scarci(Royal London Hospital), Pat Gorman(Royal London Hospital), Elisa Bertoja(Royal London Hospital), Robert Stephens(Royal London Hospital), Emilie Martinoni Hoogenboom(Royal London Hospital), James W. Holding(Royal London Hospital), Steve Bandula(Royal London Hospital), Ricky M. Thakrar(Royal London Hospital), James M. Wilson(Royal London Hospital), Mansi Shah(Royal London Hospital), Marcos Marcos(Royal London Hospital), Vasquez Duran(Royal London Hospital), Maria Litovchenko(Royal London Hospital), Sharon Vanloo(Royal London Hospital), Piotr Pawlik(Royal London Hospital), Kerstin Thol(Royal London Hospital), Babu Naidu(University Hospitals Birmingham NHS Foundation Trust), Gerald Langman(University Hospitals Birmingham NHS Foundation Trust), Hollie Bancroft(University Hospitals Birmingham NHS Foundation Trust), Salma Kadiri(University Hospitals Birmingham NHS Foundation Trust), Gary Middleton(University Hospitals Birmingham NHS Foundation Trust), Madava Djearaman(University Hospitals Birmingham NHS Foundation Trust), Aya Osman(University Hospitals Birmingham NHS Foundation Trust), Helen Shackleford(University Hospitals Birmingham NHS Foundation Trust), Akshay J. Patel(University Hospitals Birmingham NHS Foundation Trust), Christian H. Ottensmeier(University Hospital Southampton NHS Foundation Trust), Serena Chee(University Hospital Southampton NHS Foundation Trust), Aiman Alzetani(University Hospital Southampton NHS Foundation Trust), Judith Cave(University Hospital Southampton NHS Foundation Trust), Lydia Scarlett(University Hospital Southampton NHS Foundation Trust), Jennifer Richards(University Hospital Southampton NHS Foundation Trust), Papawadee Ingram(University Hospital Southampton NHS Foundation Trust), Emily Shaw(University Hospital Southampton NHS Foundation Trust), John Le Quesne(University of Glasgow), Alan G. Dawson(University of Leicester), Domenic Marrone(University of Leicester), Sean Dulloo(University of Leicester), Claire Wilson(University of Leicester), Yvonne Summers(Manchester University NHS Foundation Trust), Raffaele Califano(Manchester University NHS Foundation Trust), Rajesh Shah(Manchester University NHS Foundation Trust), Piotr Krysiak(Manchester University NHS Foundation Trust), Kendadai Rammohan(Manchester University NHS Foundation Trust), Eustace Fontaine(Manchester University NHS Foundation Trust), Richard Booton(Manchester University NHS Foundation Trust), Matthew Evison(Manchester University NHS Foundation Trust), Stuart Moss(Manchester University NHS Foundation Trust), Juliette Novasio(Manchester University NHS Foundation Trust), Leena Dennis Joseph(Manchester University NHS Foundation Trust), Paul Bishop(Manchester University NHS Foundation Trust), Helen Doran(Manchester University NHS Foundation Trust), Felice Granato(Manchester University NHS Foundation Trust), Vijay Joshi(Manchester University NHS Foundation Trust), Elaine Smith(Manchester University NHS Foundation Trust), Ángeles Montero(Manchester University NHS Foundation Trust), Philip Crosbie(Manchester University NHS Foundation Trust), Nicholas McGranahan(Cancer Research UK), Mariam Jamal‐Hanjani(Cancer Research UK), Allan Hackshaw(Cancer Research UK), Sergio A. Quezada(Cancer Research UK), Adrian Hayday(King's College London), Charles Swanton(The Francis Crick Institute)
Cited by 111Open Access
Abstract
Abstract Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8 + T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA − CD27 − effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103 + tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.