miRTarBase 2020: updates to the experimentally validated microRNA–target interaction database

Hsi‐Yuan Huang(National Yang Ming Chiao Tung University), Hsi‐Yuan Huang(National Yang Ming Chiao Tung University), Yang-Chi-Dung Lin(Chinese University of Hong Kong, Shenzhen), Jing Li(Chinese University of Hong Kong, Shenzhen), Kai‐Yao Huang(National Yang Ming Chiao Tung University), Sirjana Shrestha(National Yang Ming Chiao Tung University), Hsiao-Chin Hong(Chinese University of Hong Kong, Shenzhen), Yun Tang(Chinese University of Hong Kong, Shenzhen), Yi-Gang Chen(Chinese University of Hong Kong, Shenzhen), Chen-Nan Jin(Chinese University of Hong Kong, Shenzhen), Yuan Yu(Chinese University of Hong Kong, Shenzhen), Jiatong Xu(Chinese University of Hong Kong, Shenzhen), Yue‐Ming Li(Chinese University of Hong Kong, Shenzhen), Xiaoxuan Cai(Chinese University of Hong Kong, Shenzhen), Zhenyu Zhou(Shenzhen Maternity and Child Healthcare Hospital), Xiaohang Chen(Shenzhen Maternity and Child Healthcare Hospital), Yuanyuan Pei(Shenzhen Maternity and Child Healthcare Hospital), Liang Hu(Jiamusi University), Jinjiang Su(Jiamusi University), Shidong Cui(Chinese University of Hong Kong, Shenzhen), Fei Wang(Chinese University of Hong Kong, Shenzhen), Yueyang Xie(Chinese University of Hong Kong, Shenzhen), Si-Yuan Ding(Chinese University of Hong Kong, Shenzhen), Meng-Fan Luo(National Yang Ming Chiao Tung University), Chih‐Hung Chou(National Yang Ming Chiao Tung University), Nai‐Wen Chang(National Yang Ming Chiao Tung University), Kaiwen Chen(National Yang Ming Chiao Tung University), Yu‐Hsiang Cheng(National Yang Ming Chiao Tung University), Xinhong Wan(Institute of Information Science, Academia Sinica), Wen−Lian Hsu(Institute of Information Science, Academia Sinica), Tzong-Yi Lee(Jiamusi University), Fengxiang Wei(National Yang Ming Chiao Tung University), Hsien-Da Huang(National Yang Ming Chiao Tung University), Hsien-Da Huang(National Yang Ming Chiao Tung University)
Nucleic Acids Research
October 22, 2019
10.1093/nar/gkz896
Cited by 1,308Open Access
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Abstract

Abstract MicroRNAs (miRNAs) are small non-coding RNAs (typically consisting of 18–25 nucleotides) that negatively control expression of target genes at the post-transcriptional level. Owing to the biological significance of miRNAs, miRTarBase was developed to provide comprehensive information on experimentally validated miRNA–target interactions (MTIs). To date, the database has accumulated >13,404 validated MTIs from 11,021 articles from manual curations. In this update, a text-mining system was incorporated to enhance the recognition of MTI-related articles by adopting a scoring system. In addition, a variety of biological databases were integrated to provide information on the regulatory network of miRNAs and its expression in blood. Not only targets of miRNAs but also regulators of miRNAs are provided to users for investigating the up- and downstream regulations of miRNAs. Moreover, the number of MTIs with high-throughput experimental evidence increased remarkably (validated by CLIP-seq technology). In conclusion, these improvements promote the miRTarBase as one of the most comprehensively annotated and experimentally validated miRNA–target interaction databases. The updated version of miRTarBase is now available at http://miRTarBase.cuhk.edu.cn/.

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