Switching on a Signaling Pathway with an Organoruthenium Complex

Douglas S. Williams(University of Pennsylvania), G. Ekin Atilla(University of Pennsylvania), Howard Bregman(University of Pennsylvania), Arpine Arzoumanian(University of Pennsylvania), Peter S. Klein(Howard Hughes Medical Institute), Eric Meggers(University of Pennsylvania)
Angewandte Chemie
March 2, 2005
10.1002/ange.200462501
Cited by 23

Abstract

Wie ein organisches Molekül! Ein chemisch inerter Rutheniumkomplex, der die Proteinkinase GSK-3 an ihrer ATP-Bindungsstelle inhibiert, schaltet den Wnt-Signalweg in lebenden Zellen und in Xenopus-Embryos ein. Diese entwickeln bei Verabreichung des neuen Metallopharmazeutikums einen hyperdorsalisierten Phänotyp (im Bild oben; unten: Kontrollexemplar). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z462501_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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