Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells

Abstract

(Stem Cell Reports 2, 295–310, March 11, 2014) The Authors would like to acknowledge the JPB Foundation for the support of the work in this manuscript. Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem CellsYu et al.Stem Cell ReportsFebruary 27, 2014In BriefGage and colleagues report a differentiation paradigm for human stem cells (ESCs and IPSCs) to generate hippocampal dentate gyrus (DG) granule neurons. This paradigm recapitulates characteristic gene expressions and produces functional neurons that integrate into the DG. Differentiation of schizophrenia patient-derived IPSCs revealed deficits in hippocampal neurogenesis from the NPC population and produced DG granule neurons with reduced spontaneous transmitter release. Full-Text PDF Open Access