Application and pharmacological mechanism of methotrexate in rheumatoid arthritis
Zixuan Zhao(Beijing University of Chinese Medicine), Zhenglai Hua(Beijing University of Chinese Medicine), Xinyi Luo(Beijing University of Chinese Medicine), Yang Li(Beijing University of Chinese Medicine), Liuchunyang Yu(Beijing University of Chinese Medicine), Ming Li(Beijing University of Chinese Medicine), Cheng Lü(Chinese Academy of Medical Sciences & Peking Union Medical College), Ting Zhao(Beijing University of Chinese Medicine), Yuanyan Liu(Beijing University of Chinese Medicine)
Cited by 155Open Access
Abstract
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about forty years and to date MTX remains the part of global standard of treatment for RA. The efficacy of MTX in RA is the result of multiple mechanisms of action. In order to summarize the possible pharmacological mechanisms of MTX in the treatment of RA, this review will elaborate on folate antagonism, promotion of adenosine accumulation, regulation of inflammatory signaling pathways, bone protection and maintenance of immune system function.
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