Distinct immune cell dynamics correlate with the immunogenicity and reactogenicity of SARS-CoV-2 mRNA vaccine
Tomohiro Takano(National Institute of Infectious Diseases), Miwa Morikawa(New Tokyo Hospital), Yu Adachi(National Institute of Infectious Diseases), Kiyomi Kabasawa(New Tokyo Hospital), Nicolas Sax, Saya Moriyama(National Institute of Infectious Diseases), Lin Sun(National Institute of Infectious Diseases), Masanori Isogawa(National Institute of Infectious Diseases), Ayae Nishiyama(National Institute of Infectious Diseases), Taishi Onodera(National Institute of Infectious Diseases), Kazutaka Terahara(National Institute of Infectious Diseases), Keisuke Tonouchi(National Institute of Infectious Diseases), Masashi Nishimura(New Tokyo Hospital), Kentaro Tomii(The Open University of Japan), Kazuo Yamashita, Takayuki Matsumura(National Institute of Infectious Diseases), Masaharu Shinkai(Seiwa Hospital), Yoshimasa Takahashi(National Institute of Infectious Diseases)
Cited by 56Open Access
Abstract
[AS]-DCs), and NKT-like cells are revealed as the distinct cell correlates for neutralizing-antibody titers, severity of adverse events, and both, respectively. The cell correlates for neutralizing antibodies or adverse events are consistently associated with elevation of interferon gamma (IFN-γ)-inducible chemokines, but the chemokine receptors CCR2 and CXCR3 are expressed in distinct manners between the two correlates: vaccine-induced expression on the neutralizing-antibody correlate and constitutive expression on the adverse-event correlate. The finding may guide vaccine strategies that balance immunogenicity and reactogenicity.
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