Demonstration of a Common DPhe <sup>7</sup> to DNal(2′) <sup>7</sup> Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides

Luis E. Gimenez(University of Michigan), Terry A. Noblin(University of Michigan), Savannah Y. Williams(University of Michigan), Satarupa Mullick Bagchi(University of Michigan), Renlei Ji(Auburn University), Ya‐Xiong Tao(Auburn University), Claus Jeppesen(Novo Nordisk (Denmark)), Kilian W. Conde‐Frieboes(Novo Nordisk (Denmark)), Tomi K. Sawyer, Paolo Grieco(Centro Interuniversitario di Ricerca sui Peptidi Bioattivi), Roger D. Cone(University of Michigan)
Journal of Medicinal Chemistry
April 11, 2022
10.1021/acs.jmedchem.1c01295
Cited by 10Open Access
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Abstract

-containing peptides date back to 2003; thus, our analysis suggests that systematic mischaracterization of the pharmacological properties of melanocortin peptides occurred.

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