Continuous stirred-tank reactor cascade platform for self-optimization of reactions involving solids

Kakasaheb Y. Nandiwale(Massachusetts Institute of Technology), Travis Hart(Massachusetts Institute of Technology), Andrew F. Zahrt(Massachusetts Institute of Technology), Anirudh M. K. Nambiar(Massachusetts Institute of Technology), Prajwal T. Mahesh(Massachusetts Institute of Technology), Yiming Mo(Massachusetts Institute of Technology), María José Nieves‐Remacha(Eli Lilly (Spain)), Martin D. Johnson(Eli Lilly (United States)), Pablo García‐Losada(Eli Lilly (Spain)), Carlos Mateos(Eli Lilly (Spain)), Juan A. Rincón(Eli Lilly (Spain)), Klavs F. Jensen(Massachusetts Institute of Technology)
Reaction Chemistry & Engineering
January 1, 2022
10.1039/d2re00054g
Cited by 49Open Access
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Abstract

Research-scale fully automated flow platform for reaction self-optimization with solids handling facilitates identification of optimal conditions for continuous manufacturing of pharmaceuticals while reducing amounts of raw materials consumed.

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