Integrative clinical and molecular characterization of translocation renal cell carcinoma

Ziad Bakouny(Broad Institute), Ananthan Sadagopan(Dana-Farber Cancer Institute), Praful Ravi(Dana-Farber Cancer Institute), Nebiyou Y. Metaferia(Dana-Farber Cancer Institute), Jiao Li(Dana-Farber Cancer Institute), Shatha AbuHammad(Broad Institute), Stephen Tang(Dana-Farber Cancer Institute), Thomas Denize(Brigham and Women's Hospital), Emma R. Garner(Dana-Farber Cancer Institute), Xīn Gào(Harvard University), David A. Braun(Broad Institute), Laure Hirsch(Harvard University), John A. Steinharter(Dana-Farber Cancer Institute), Gabrielle Bouchard(Dana-Farber Cancer Institute), Emily Walton(Brigham and Women's Hospital), Destiny West(Brigham and Women's Hospital), Chris Labaki(Dana-Farber Cancer Institute), Shaan Dudani(William Osler Health System), Chun-Loo Gan(University of Calgary), Vidyalakshmi Sethunath(Dana-Farber Cancer Institute), Filipe L.F. Carvalho(Brigham and Women's Hospital), Alma Imamović(Dana-Farber Cancer Institute), Cora A. Ricker(Dana-Farber Cancer Institute), Natalie I. Vokes(The University of Texas MD Anderson Cancer Center), Jackson Nyman(Dana-Farber Cancer Institute), Jacob E. Berchuck(Dana-Farber Cancer Institute), Jihye Park(Broad Institute), Michelle S. Hirsch(Brigham and Women's Hospital), Rizwan Haq(Broad Institute), Gwo‐Shu Mary Lee(Dana-Farber Cancer Institute), Bradley A. McGregor(Dana-Farber Cancer Institute), Steven L. Chang(Brigham and Women's Hospital), Adam S. Feldman(Massachusetts General Hospital), Catherine J. Wu(Broad Institute), David F. McDermott(Beth Israel Deaconess Medical Center), Daniel Yick Chin Heng(University of Calgary), Sabina Signoretti(Brigham and Women's Hospital), Eliezer M. Van Allen(Broad Institute), Toni K. Choueiri(Brigham and Women's Hospital), Srinivas R. Viswanathan(Broad Institute)
Cell Reports
January 1, 2022
10.1016/j.celrep.2021.110190
Cited by 115Open Access
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Abstract

T cells, though the T cells harbor an exhaustion immunophenotype distinct from that of clear cell RCC. Our findings comprehensively define the clinical and molecular features of tRCC and may inspire new therapeutic hypotheses.

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