Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors

Bram Herpers, Berina Eppink(Merus (Netherlands)), Mark I. James(Institute for Research in Biomedicine), Carme Cortina(Institute for Research in Biomedicine), Adrià Cañellas‐Socias(Institute for Research in Biomedicine), Sylvia F. Boj, Xavier Hernando‐Momblona(Institute for Research in Biomedicine), Dominik Głodzik(Harvard University), Rob C. Roovers(Merus (Netherlands)), Marc van de Wetering(Royal Netherlands Academy of Arts and Sciences), Carina Bartelink-Clements(Merus (Netherlands)), Vanessa Zondag-van der Zande(Merus (Netherlands)), Jara García Mateos, Kuan Yan, Lucia Salinaro, Abdul Basmeleh(Merus (Netherlands)), Szabolcs Fátrai(Merus (Netherlands)), David Maussang(Merus (Netherlands)), Jeroen J. Lammerts van Bueren(Merus (Netherlands)), Irene Chicote(Vall d'Hebron Institute of Oncology), Garazi Serna(Vall d'Hebron Institute of Oncology), Laia Cabellos(Vall d'Hebron Hospital Universitari), Lorena Ramírez(Vall d'Hebron Hospital Universitari), Paolo Nucíforo(Vall d'Hebron Institute of Oncology), Ramón Salazar(Institut d'Investigació Biomédica de Bellvitge), Cristina Santos(Institut d'Investigació Biomédica de Bellvitge), Alberto Villanueva(Bellvitge University Hospital), Camille Stephan‐Otto Attolini(Institute for Research in Biomedicine), Elena Sancho(Institute for Research in Biomedicine), Héctor G. Pálmer(Vall d'Hebron Hospital Universitari), Josep Tabernero(Vall d'Hebron Hospital Universitari), Michael R. Stratton(Wellcome Sanger Institute), John de Kruif(Merus (Netherlands)), Ton Logtenberg(Merus (Netherlands)), Hans Clevers(Royal Netherlands Academy of Arts and Sciences), Leo Price, Robert G.J. Vries, Eduard Batlle(Institució Catalana de Recerca i Estudis Avançats), Mark Throsby(Merus (Netherlands))
Nature Cancer
April 25, 2022
Cited by 155Open Access
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