Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

Brian Golbourn; Matthew Halbert; Katharine Halligan; Srinidhi Varadharajan; Brian Krug; Nneka E. Mbah; Nisha Kabir; Ann-Catherine J. Stanton; Abigail L. Locke; Stephanie M. Casillo; Yanhua Zhao; Lauren Sanders; Allison Cheney; Steven J. Mullett; Apeng Chen; Michelle Wassell; Anthony Andren; Jennifer Pérez; Esther P. Jane; Daniel R. Premkumar; Robert F. Koncar; Shideh Mirhadi; Lauren McCarl; Yue‐Fang Chang; Yijen Wu; Taylor Gatesman; Andrea Cruz; Michal Zápotocký; Baoli Hu; Gary Kohanbash; Xiuxing Wang; Alenoush Vartanian; Michael F. Moran; Frank S. Lieberman; Nduka Amankulor; Stacy G. Wendell; Olena M. Vaske; Ashok Panigrahy; James Felker; Kelsey C. Bertrand; Claudia L. Kleinman; Jeremy N. Rich; Robert M. Friedlander; Alberto Broniscer; Costas A. Lyssiotis; Nada Jabado; Ian F. Pollack; Stephen C. Mack; Sameer Agnihotri

doi:10.1038/s43018-022-00348-3

Loss of MAT2A compromises methionine metabolism and represents a vulnerability in H3K27M mutant glioma by modulating the epigenome

Brian Golbourn(University of Pittsburgh), Matthew Halbert(University of Pittsburgh), Katharine Halligan(University of Pittsburgh), Srinidhi Varadharajan(Baylor College of Medicine), Brian Krug(McGill University Health Centre), Nneka E. Mbah(University of Michigan), Nisha Kabir(Jewish General Hospital), Ann-Catherine J. Stanton(University of Pittsburgh), Abigail L. Locke(University of Pittsburgh), Stephanie M. Casillo(University of Pittsburgh), Yanhua Zhao(Baylor College of Medicine), Lauren Sanders(University of California, Santa Cruz), Allison Cheney(University of California, Santa Cruz), Steven J. Mullett(University of Pittsburgh), Apeng Chen(University of Pittsburgh), Michelle Wassell(University of Pittsburgh), Anthony Andren(University of Michigan), Jennifer Pérez(University of Pittsburgh), Esther P. Jane(University of Pittsburgh), Daniel R. Premkumar(University of Pittsburgh), Robert F. Koncar(University of Pittsburgh), Shideh Mirhadi(University of Toronto), Lauren McCarl(University of Pittsburgh), Yue‐Fang Chang(University of Pittsburgh), Yijen Wu(University of Pittsburgh), Taylor Gatesman(University of Pittsburgh), Andrea Cruz(University of Pittsburgh), Michal Zápotocký(Charles University), Baoli Hu(University of Pittsburgh), Gary Kohanbash(University of Pittsburgh), Xiuxing Wang(Nanjing Medical University), Alenoush Vartanian(Shadyside Hospital), Michael F. Moran(University of Toronto), Frank S. Lieberman(UPMC Hillman Cancer Center), Nduka Amankulor(University of Pittsburgh), Stacy G. Wendell(University of Pittsburgh), Olena M. Vaske(University of California, Santa Cruz), Ashok Panigrahy(Children's Hospital of Pittsburgh), James Felker(Children's Hospital of Pittsburgh), Kelsey C. Bertrand(St. Jude Children's Research Hospital), Claudia L. Kleinman(Jewish General Hospital), Jeremy N. Rich(University of Pittsburgh), Robert M. Friedlander(University of Pittsburgh), Alberto Broniscer(Children's Hospital of Pittsburgh), Costas A. Lyssiotis(University of Michigan), Nada Jabado(McGill University Health Centre), Ian F. Pollack(University of Pittsburgh), Stephen C. Mack(St. Jude Children's Research Hospital), Sameer Agnihotri(University of Pittsburgh)

Nature Cancer

April 14, 2022

10.1038/s43018-022-00348-3

Cited by 90Open Access

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