Engineering T-Cell Resistance to HIV-1 Infection via Knock-In of Peptides from the Heptad Repeat 2 Domain of gp41
Alexandra Maslennikova(Institute of Gene Biology), Natalia Kruglova(Institute of Gene Biology), С. В. Калиниченко(Institute of Gene Biology), Dmitriy Komkov(Institute of Gene Biology), М. В. Шепелев(Institute of Gene Biology), Dmitriy Golubev(Institute of Gene Biology), Andrei E. Siniavin(Gamalei Institute of Epidemiology and Microbiology), Andrei N. Vzorov(Lomonosov Moscow State University), Alexander Filatov(Lomonosov Moscow State University), Dmitriy Mazurov(Institute of Gene Biology)
Cited by 18Open Access
Abstract
HIV is a human lentivirus that infects CD4-positive immune cells and, when left untreated, manifests in the fatal disease known as AIDS. Antiretroviral therapy (ART) does not leading to viral clearance, and HIV persists in the organism as a latent provirus.
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