Local connectivity and synaptic dynamics in mouse and human neocortex
Luke Campagnola(Allen Institute for Brain Science), Stephanie C. Seeman(Allen Institute for Brain Science), Thomas Chartrand(Allen Institute for Brain Science), Lisa Kim(Allen Institute for Brain Science), Alex Hoggarth(Allen Institute for Brain Science), Clare Gamlin(Allen Institute for Brain Science), Shinya Ito(Allen Institute for Brain Science), Jessica Trinh(Allen Institute for Brain Science), Pasha A. Davoudian(Allen Institute for Brain Science), Cristina Radaelli(Allen Institute for Brain Science), Mean-Hwan Kim(Allen Institute for Brain Science), Travis A Hage(Allen Institute for Brain Science), Thomas Braun, Lauren Alfiler(Allen Institute for Brain Science), Júlia Andrade(Allen Institute for Brain Science), Phillip Bohn(Allen Institute for Brain Science), Rachel Dalley(Allen Institute for Brain Science), Alex M. Henry(Allen Institute for Brain Science), Sara Kebede(Allen Institute for Brain Science), Alice Mukora(Allen Institute for Brain Science), David Sandman(Allen Institute for Brain Science), Grace Williams(Allen Institute for Brain Science), Rachael Larsen(Allen Institute for Brain Science), Corinne Teeter(Allen Institute for Brain Science), Tanya L. Daigle(Allen Institute for Brain Science), Kyla Berry(Allen Institute for Brain Science), Nadia Dotson(Allen Institute for Brain Science), Rachel Enstrom(Allen Institute for Brain Science), Melissa Gorham(Allen Institute for Brain Science), Madie Hupp(Allen Institute for Brain Science), Samuel Dingman Lee(Allen Institute for Brain Science), Kiet Ngo(Allen Institute for Brain Science), Philip R. Nicovich(Allen Institute for Brain Science), Lydia Potekhina(Allen Institute for Brain Science), Shea Ransford(Allen Institute for Brain Science), Amanda Gary(Allen Institute for Brain Science), Jeff Goldy(Allen Institute for Brain Science), Delissa McMillen(Allen Institute for Brain Science), Trangthanh Pham(Allen Institute for Brain Science), Michael Tieu(Allen Institute for Brain Science), La’Akea Siverts(Allen Institute for Brain Science), Miranda Walker(Allen Institute for Brain Science), Colin Farrell(Allen Institute for Brain Science), Martin Schroedter(Allen Institute for Brain Science), Cliff Slaughterbeck(Allen Institute for Brain Science), Charles Cobb(Swedish Medical Center), Richard G. Ellenbogen(University of Washington), Ryder P. Gwinn(Swedish Medical Center), C. Dirk Keene(University of Washington), Andrew L. Ko(University of Washington), Jeffrey G. Ojemann(University of Washington), Daniel L. Silbergeld(University of Washington), Daniel Carey(Allen Institute for Brain Science), Tamara Casper(Allen Institute for Brain Science), Kirsten Crichton(Allen Institute for Brain Science), Michael Clark(Allen Institute for Brain Science), Nick Dee(Allen Institute for Brain Science), Lauren Ellingwood(Allen Institute for Brain Science), Jessica Gloe(Allen Institute for Brain Science), Matthew Kroll(Allen Institute for Brain Science), Josef Šulc(Allen Institute for Brain Science), Herman Tung(Allen Institute for Brain Science), Katherine Wadhwani(Allen Institute for Brain Science), Krissy Brouner(Allen Institute for Brain Science), Tom Egdorf(Allen Institute for Brain Science), Michelle Maxwell(Allen Institute for Brain Science), Mary McGraw(Allen Institute for Brain Science), Christina Alice Pom(Allen Institute for Brain Science), Augustin Ruiz(Allen Institute for Brain Science), Jasmine Bomben(Allen Institute for Brain Science), David Feng(Allen Institute for Brain Science), Nika Hejazinia(Allen Institute for Brain Science), Shi Shu(Allen Institute for Brain Science), Aaron Szafer(Allen Institute for Brain Science), Wayne Wakeman(Allen Institute for Brain Science), John W. Phillips(Allen Institute for Brain Science), Amy Bernard(Allen Institute for Brain Science), Luke Esposito(Allen Institute for Brain Science), Florence D. D’Orazi(Allen Institute for Brain Science), Susan M. Sunkin(Allen Institute for Brain Science), Kimberly A. Smith(Allen Institute for Brain Science), Bosiljka Tasic(Allen Institute for Brain Science), Anton Arkhipov(Allen Institute for Brain Science), Staci A. Sorensen(Allen Institute for Brain Science), Ed S. Lein(Allen Institute for Brain Science), Christof Koch(Allen Institute for Brain Science), Gabe J. Murphy(Allen Institute for Brain Science), Hongkui Zeng(Allen Institute for Brain Science), Tim Jarsky(Allen Institute for Brain Science)
Cited by 379Open Access
Abstract
We present a unique, extensive, and open synaptic physiology analysis platform and dataset. Through its application, we reveal principles that relate cell type to synaptic properties and intralaminar circuit organization in the mouse and human cortex. The dynamics of excitatory synapses align with the postsynaptic cell subclass, whereas inhibitory synapse dynamics partly align with presynaptic cell subclass but with considerable overlap. Synaptic properties are heterogeneous in most subclass-to-subclass connections. The two main axes of heterogeneity are strength and variability. Cell subclasses divide along the variability axis, whereas the strength axis accounts for substantial heterogeneity within the subclass. In the human cortex, excitatory-to-excitatory synaptic dynamics are distinct from those in the mouse cortex and vary with depth across layers 2 and 3.
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