Mechanistic convergence of the TIGIT and PD-1 inhibitory pathways necessitates co-blockade to optimize anti-tumor CD8+ T cell responses
Karl L. Banta, Xiaozheng Xu(University of California San Diego), Avantika S. Chitre, Amelia Au‐Yeung, Chikara Takahashi, William O’Gorman, Thomas D. Wu, Stephanie Mittman, Rafael Cubas, Laëtitia Comps‐Agrar, Amit Fulzele(University of California San Diego), Eric J. Bennett(University of California San Diego), Jane L. Grogan, Enfu Hui(University of California San Diego), Eugene Y. Chiang(Genesys (United States)), Ira Mellman(Genesys (United States))
Cited by 344Open Access
Abstract
T cell responses, requires blockade of TIGIT and PD-1, providing a mechanistic rationale for combinatorial targeting in the clinic.
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