Clostridioides difficile Infection Dysregulates Brain Dopamine Metabolism
Akhil A. Vinithakumari(Iowa State University), Piyush Padhi(Iowa State University), Belén Hernández(Iowa State University), Susanne Je-Han Lin(Iowa State University), Aaron Dunkerson-Kurzhumov(Iowa State University), Lucas Showman(Iowa State University), Matthew W. Breitzman(Iowa State University), Caroline Stokes(Iowa State University), Yousuf Sulaiman(Iowa State University), Chandra S. Tangudu(Iowa State University), Deepa Kuttappan(University of Connecticut), Muhammed Shafeekh Muyyarikkandy(University of Connecticut), Auriel A. Willette(Iowa State University), Gregory J. Phillips(Iowa State University), Vellareddy Anantharam(University of Georgia), Ann Perera(Iowa State University), Brett A. Sponseller(Iowa State University), Anumantha G. Kanthasamy(University of Georgia), Shankumar Mooyottu(Iowa State University)
Cited by 30Open Access
Abstract
The gut-brain axis is thought to play a significant role in the development and manifestation of neurologic diseases. This study reports significant alterations in the brain dopamine metabolism in mice infected with C. difficile, an important pathogen that overgrows in the gut after prolonged antibiotic therapy. Such alterations in specific brain regions may have an effect on the precipitation or manifestation of neurodevelopmental disorders in humans.
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